Title:Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors
VOLUME: 20 ISSUE: 10
Author(s):Dima A. Sabbah*, Rima Hajjo and Kamal Sweidan
Affiliation:Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Department of Chemistry, The University of Jordan, Amman 11942
Keywords:EGFR, HER-1, ERBB-1, Tyrosine kinase, EGF, TGF-α, mAbs, Inhibitors, cancer.
Abstract:The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival,
and cancer development. In this review, the EGFR structure and its mutations, signaling pathway,
ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of
EGFR inhibitors have been explored.
