The Role of Serum Procalcitonin Level as an Early Marker of Ascitic Fluid Infection in Post Hepatitic Cirrhotic Patients

Author(s): Mohamed Zakaria Abu Rahma, Zainab Gaber Mahran, Engy Adel Shafik, Dina Ahmed Mohareb, Nessren M. Abd El-Rady, Mohamed A. Mustafa, Mahmoud Khalil, Yousry Esam-Eldin Abo-Amer, Sherief Abd-Elsalam*

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 20 , Issue 1 , 2021

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Graphical Abstract:


Aims & Background: The early diagnosis of spontaneous bacterial peritonitis (SBP) has been considered important in the overall patient’s survival. Ascitic fluid culture examination performance, in the emergency setting, is time-consuming and not always available, so there is a need for easy to apply, rapid and reliable markers for diagnosis of patients with ascites. The present prospective study aimed to determine the early diagnostic value of serum procalcitonin (PCT) levels in decompensated cirrhotic patients (DCPs) with SBP.

Methods: 47 HCV cirrhotic patients with ascites were enrolled for this prospective study. The severity of cirrhosis was classified based on the Child–Pugh criteria. All patients were subjected to paracentesis and ascitic fluid (AF) culture. Serum PCT levels were measured using enzyme-linked fluorescence analysis (ELFA).

Results: The diagnostic value of serum PCT levels and WBC/PLT ratios for detecting infections were serum PCT levels (3.63 ± 3.47 ng/mL) in DCPs with infections which were significantly higher than in DCPs without infections (0.505 ± 0.230 ng/mL); p < 0.05. The cut-off value for serum PCT levels was 0.7 ng/mL for the diagnosis of infections in DCPs, for which the sensitivity and specificity were 93.1% and 73.2%, respectively. The AUC was 0.91 (95% CI: 0.83-0.99).

Conclusion: Serum procalcitonin seems to provide satisfactory diagnostic biomarkers in SBP.

Keywords: Cirrhosis, ascites, SBP, procalcitonin, biomarker, diagnosis.

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Article Details

Year: 2021
Published on: 10 March, 2021
Page: [61 - 67]
Pages: 7
DOI: 10.2174/1871523019666200303104932
Price: $65

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