Background: Postoperative Nausea and Vomiting (PONV) is a common complication
associated with the use of anesthesia. Several antiemetics are used to reduce the incidence and severity
of PONV. The aim of this study was to investigate the role of dexamethasone and ondansetron
to treat PONV in patients undergoing cesarean section (c-section) under spinal anesthesia.
Methods: This double-blind clinical trial study was performed on patients who were referred to
Haji Karim Asali Hospital of Khorramabad for elective cesarean section in 2016-17. Upon meeting
the inclusion criteria, patients were allotted into two groups (n=60). Group A received 8mg of dexamethasone
and group B received 4mg of ondansetron after spinal anesthesia. The Visual Analog
Scale (VAS) questionnaire and Depression-Anxiety-Stress Scale (DASS) questionnaire were used
for the analysis. Patients with mild to moderate stress, anxiety, and depression were included in the
study. Data were analyzed using SPSS 16 software.
Results: There was no difference in the demographic data of the two groups. The mean severity of
nausea in group A was significantly higher than in group B. The odd ration of PONV was 20.67,
which was found to be statistically significant, p = 0.018. Concerning the type of delivery with the
frequency of nausea, the results showed that the frequency of nausea in group A was 3.24 times
higher than group B, however, this difference was not statistically significant, p = 0.106.
Conclusion: Based on the results of this study, ondansetron had a significant effect on the alleviation
of postoperative nausea and vomiting, as compared to dexamethasone in C-section surgical