Background: Pistacia lentiscus L. (Lentisk) an evergreen tree or shrub that is ubiquitous
across the semi-arid areas of the Mediterranean and native to all Mediterranean islands. All
parts of Lentisk, including resin, leaves, gum, fruits, and aerial parts, have been used as valuable
remedies for various diseases since antiquity.
Objective: This paper highlights a novel source for the isolation of pure shikimic acid from the Lentisk
ethyl acetate extract, which could provide an alternative and renewable solution for shikimic
acid in the future.
Methods: Characterisation by melting point, elemental analysis, FTIR, HRMS, 1H-NMR, DEPT(
135)-NMR, and 13C-NMR spectroscopy confirmed the purity of shikimic acid. The antioxidant
activity of Lentisk extract and shikimic acid was performed by DPPH free radical scavenging activity
Results: The results prove that Lentisk is an alternative and renewable source of shikimic acid.
With regard to activity, the shikimic acid does not act as the lead compound in the antioxidant activity
of Lentisk extract.
Conclusion: Lentisk is a novel alternative and renewable source of shikimic acid.