Review on Chemistry, Analysis and Pharmacology of Teneligliptin: A Novel DPP-4 Inhibitor

Author(s): Sanjay Sharma*, Raksha Sharma, Ketan Hatware, Kiran Patil

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 12 , 2020

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Graphical Abstract:


This article provides comprehensive and collective facts about teneligliptin. Teneligliptin is a dipeptide peptidase-4 (DPP-4) inhibitor that belongs to the third generation, used in the management of type 2 diabetes. It inhibits human DPP-4 enzyme activity. This drug falls under class 3; it interacts with S1, S2, and S2E extensive sub-sites. Teneligliptin and its metabolites are mainly determined in the human plasma matrix by hyphenated chromatographic methods. These developed methods could be foreseen for their clinical applications. Moreover, the stress degradation studies of Teneligliptin under different stress conditions provide an insight into degradation pathways and help in the elucidation of the structure of the degradation products by liquid mass spectroscopy. These methods are also used for routine quality control analysis of teneligliptin in pharmaceutical dosage forms.

Keywords: Teneligliptin, identification, pharmacokinetics, pharmacodynamics, chemistry, analysis.

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Article Details

Year: 2020
Page: [1091 - 1100]
Pages: 10
DOI: 10.2174/1389557520666200228144148
Price: $65

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