A General Method for the Synthesis of 3,3-bis(indol-3-yl)indolin-2-ones, bis(indol-3-yl)(aryl)methanes and tris(indol-3-yl)methanes Using Naturally Occurring Mandelic Acid as an Efficient Organo-catalyst in Aqueous Ethanol at Room Temperature

Author(s): Arvind Singh, Gurpreet Kaur, Amninder Kaur, Vivek K. Gupta, Bubun Banerjee*

Journal Name: Current Green Chemistry

Volume 7 , Issue 1 , 2020


DOI : 10.2174/2213346107666200228125715

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Graphical Abstract:


Abstract:

A simple, facile, straightforward and environmentally benign protocol has been developed for the efficient synthesis of pharmaceutically interesting 3,3-bis(indol-3-yl)indolin-2-ones, bis(indol- 3-yl)(aryl)methanes and tris(indol-3-yl)methanes using a catalytic amount of mandelic acid as an efficient, naturally occurring, low-cost, commercially available organo-catalyst in aqueous ethanol at room temperature.

Keywords: bis(indol-3-yl)(aryl)methanes, 3, 3-bis(indol-3-yl)indolin-2-ones, tris(1H-indol-3-yl)methane, mandelic acid, room temperature, sustainable synthesis.

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VOLUME: 7
ISSUE: 1
Year: 2020
Published on: 14 May, 2020
Page: [128 - 140]
Pages: 13
DOI: 10.2174/2213346107666200228125715
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