Aims: The aim of the study was to study the antidiabetic effect of Traganum nudatum in
an animal model of diabetes.
Background: Traganum nudatum (T. nudatum) is a medicinal plant widely used in folk medicine by
the Moroccan population to treat various diseases including diabetes.
Objective: The objective of the study was to evaluate the antihyperglycemic and hypoglycemic of the
aqueous Traganum nudatum extract in normal and streptozotocin-induced diabetic rats.
Methods: Normal and streptozotocin-induced diabetic rats were treated orally by the extract of
Traganum nudatum (T. nudatum) at a dose of 50 mg/kg. The blood glucose levels were determined
for 6 hours and 15 days during this treatment. The oral glucose tolerance and phytochemical tests and
the analysis of histopathological changes of the liver were performed. The antioxidant activity of
aqueous T. nudatum extract was also assessed using the method of trapping of free radical 2,2-
diphenyl-1 picrylhydrazyl (DPPH).
Results: T. nudatum Aerial Part Aqueous Extract (TNAPAE) reduced the blood glucose levels in
both normal and diabetic rats. The results demonstrated that TNAPAE treatment exhibited a significant
hypoglycemic effect without altering the body weight. In addition, a noticeable influence on
glucose tolerance was also observed after TNAPAE treatment. Moreover, TNAPAE was able to exhibit
a beneficial effect on the histological structure of the liver. Finally, a potential antioxidant effect
has been shown in vitro.
Conclusion: In conclusion, this study demonstrates the antihyperglycemic and hypoglycemic effects
of T. nudatum in rats supporting its traditional use for the management of diabetes.