Biological Signatures of Alzheimer’s Disease

Author(s): Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode*, Faheem H. Pottoo

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 9 , 2020

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Abstract:

Alzheimer’s disease (AD) is the most prevalent and severe neurodegenerative disease affecting more than 0.024 billion people globally, more common in women as compared to men. Senile plaques and amyloid deposition are among the main causes of AD. Amyloid deposition is considered as a central event which induces the link between the production of β amyloid and vascular changes. Presence of numerous biomarkers such as cerebral amyloid angiopathy, microvascular changes, senile plaques, changes in white matter, granulovascular degeneration specifies the manifestation of AD while an aggregation of tau protein is considered as a primary marker of AD. Likewise, microvascular changes, activation of microglia (immune defense system of CNS), amyloid-beta aggregation, senile plaque and many more biomarkers are nearly found in all Alzheimer’s patients. It was seen that 70% of Alzheimer’s cases occur due to genetic factors. It has been reported in various studies that apolipoprotein E(APOE) mainly APOE4 is one of the major risk factors for the later onset of AD. Several pathological changes also occur in the white matter which include dilation of the perivascular space, loss of axons, reactive astrocytosis, oligodendrocytes and failure to drain interstitial fluid. In this review, we aim to highlight the various biological signatures associated with the AD which may further help in discovering multitargeting drug therapy.

Keywords: Alzheimer's disease, Neurodegenerative disorders, Dementia, Neurofibrillary tangles, Microvascular degeneration, Cerebral amyloid angiopathy.

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Article Details

VOLUME: 20
ISSUE: 9
Year: 2020
Page: [770 - 781]
Pages: 12
DOI: 10.2174/1568026620666200228095553
Price: $65

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