Background: Allicin from garlic is known for different medical uses for centuries. One
important explanation for these effects is the chemical reactivity of allicin as a thiosulfinate
towards thiol-groups and the modification of thiol-groups by thioallylation.
Objective: It has been shown that thioallylation can inhibit the enzymatic function of proteins. In
different organisms, the thioallylated proteins upon allicin treatment have been examined. It was
found, especially in human T-cell lymphocytes (Jurkat-cells), that the glycolysis is a major target
for allicin. Here, we briefly discuss that affecting the primary metabolism is a possible part of
allicin’s physiological functions and might be, both from therapeutic and nutraceutical view, of
particular interest for the application of allicin as an active principle of freshly damaged garlic.
Conclusion: This might, in summary, explain a possible further mode of action of allicin on cells
by changing the metabolism as the central life process and thus influencing the overall structure of
the physiological processes in the cell, which can lead to the multitude of consequences caused by