Background: Cancer is characterized by overexpression of p53 associated proteins, which
down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the
interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein.
Objective: In the current, study in silico approaches were adapted to use a natural product as a source
of cancer therapy.
Methods: In the current study in silico approaches were adapted to use a natural product as a source of
cancer therapy. For in silico studies, Chemdraw and Molecular Operating Environment were used for
structure drawing and molecular docking, respectively. Flavonoids isolated from D. carota were
docked with cancerous proteins.
Result: Based on the docking score analysis, we found that compound 7 was the potent inhibitor of
both cancerous proteins and can be used as a potent molecule for inhibition of 2N0W and 4JGR interaction
Conclusion: Thus the compound 7 can be used for the revival of p53 signaling pathway function however,
intensive in vitro and in vivo experiments are required to prove the in silico analysis.