A straightforward and efficient synthesis of acridine derivatives via a copper-catalyzed cascade
reaction among isoxazoles and diaryliodonium salts is achieved. Various mono-, multi-substituted
and 9-substituted acridine derivatives could be obtained in moderate to good yields. The process has
gone through tandem double arylation and Friedel-Crafts reactions.
Keywords: Synthetic methods, Cu-Catalyzed, Cascade Reaction, Diaryliodonium salts, Isoxazole, Acridine.
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