Title:Cu-Catalyzed Cascade Reaction of Isoxazoles with Diaryliodonium Salts for the Synthesis of Acridines
VOLUME: 17 ISSUE: 12
Author(s):Shangrong Zhu, Xuechen Lu, Qiuneng Xu, Jian Li* and Shenghu Yan*
Affiliation:School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164
Keywords:Synthetic methods, Cu-Catalyzed, Cascade Reaction, Diaryliodonium salts, Isoxazole, Acridine.
Abstract:A straightforward and efficient synthesis of acridine derivatives via a copper-catalyzed cascade
reaction among isoxazoles and diaryliodonium salts is achieved. Various mono-, multi-substituted
and 9-substituted acridine derivatives could be obtained in moderate to good yields. The process has
gone through tandem double arylation and Friedel-Crafts reactions.