Cu-Catalyzed Cascade Reaction of Isoxazoles with Diaryliodonium Salts for the Synthesis of Acridines

Author(s): Shangrong Zhu, Xuechen Lu, Qiuneng Xu, Jian Li*, Shenghu Yan*

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 12 , 2020

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Graphical Abstract:


A straightforward and efficient synthesis of acridine derivatives via a copper-catalyzed cascade reaction among isoxazoles and diaryliodonium salts is achieved. Various mono-, multi-substituted and 9-substituted acridine derivatives could be obtained in moderate to good yields. The process has gone through tandem double arylation and Friedel-Crafts reactions.

Keywords: Synthetic methods, Cu-Catalyzed, Cascade Reaction, Diaryliodonium salts, Isoxazole, Acridine.

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Article Details

Year: 2020
Published on: 08 December, 2020
Page: [944 - 950]
Pages: 7
DOI: 10.2174/1570178617666200225125427
Price: $65

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