A series of new 2-((1-((1-(4-methoxy-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)1H-indol-
3-yl)me thylene)malononitrile derivatives were synthesized by the 1,3-dipolar cycloaddition
reaction (click reaction) of 2-((1-(prop-2-yn-1-yl)-1H-indol-3-yl)methylene)malononitrile with different
aryl azides in the presence of sodium ascorbate and copper sulphate in good yields. The advantages
of this method are efficient, clean, high yields, easy workup procedures, and shorter reaction time.
These reactions are very facile, giving products by simple processing that does not require purification
by column chromatography. Spectroscopic methods confirmed all the newly synthesized compounds.
Keywords: Knoevengal condensation, 1, 2, 3-triazole, N-propargylation, click chemistry, Aryl azides, step-wise synthesis and
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