Overview of Therapeutic Effects of Statins on Inflammatory Diseases Through Regulating Adhesive Molecules

Author(s): Yibin Meng, Youhan Wang, Yibing li, Song Chon, Dingjun Hao*

Journal Name: Current Stem Cell Research & Therapy

Volume 15 , Issue 7 , 2020

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Abstract:

Simvastatin, lovastatin, rosuvastatin, pravastatin and cerivastatin belong to the statin family, which are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A. As the rate-limiting enzyme in the pathway of cholesterol metabolism, statins are classically prescribed to patients as lipidlowering agents. However, statins also possess several extra bioactivities, including anti-inflammatory, antiviral and anti-tumor. Interestingly, the most essential mechanism of these activities is that statins could regulate the expression of cell adhesion molecules (CAMs), especially, targeting lymphocytes function-associated molecules (LFA)-1, macrophage (Mac)-1 and intercellular adhesion molecules (ICAM)-1. Therefore, in this paper, we discussed the regulatory effect of statins on CAMs among different diseases. In addition, we provided speculation for the role of statins in treating orthopedic disease.

Keywords: Statins, inflammation, CAM, LFA-1, Mac-1, cardiovascular disease.

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Article Details

VOLUME: 15
ISSUE: 7
Year: 2020
Page: [614 - 622]
Pages: 9
DOI: 10.2174/1574888X15666200225092749
Price: $65

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