Antimicrobial Adjuvants - A Novel Approach to Manage Antimicrobial Resistance

Author(s): Chirag Patel*, Sanjeev Acharya, Priyanka Patel

Journal Name: Anti-Infective Agents
Formerly Anti-Infective Agents in Medicinal Chemistry

Volume 18 , Issue 4 , 2020

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Graphical Abstract:


Antibiotic resistance is one of the most prevalent, complex and serious global health issues, and needs to be monitored and controlled with medicine. Many approaches have been used to reduce the emergence and impact of resistance to antibiotics. The antimicrobial adjuvant approach is considered as novel, more effective and less expensive. The said approach not only suppresses the emergence of resistance but also conserves the activity of existing antibiotics by offering a promising strategy that is also complementary to the discovery of new antibiotics. This review contains an outline of the basic types of antibiotic adjuvant, their structure, the basis of their operation, their substrate antibiotics and the challenges in this field, as well as the role of potential compounds, namely β-lactamase inhibitors, efflux pump inhibitors and permeability enhancers in antibiotic resistance and their possible solutions.

Keywords: Antibiotic, antimicrobial resistance, efflux pump, inhibitors, antimicrobial adjuvant, β-lactamase.

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Article Details

Year: 2020
Published on: 04 January, 2021
Page: [315 - 325]
Pages: 11
DOI: 10.2174/2211352518666200224093739
Price: $25

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