Title:Antimicrobial Adjuvants - A Novel Approach to Manage Antimicrobial Resistance
VOLUME: 18 ISSUE: 4
Author(s):Chirag Patel*, Sanjeev Acharya and Priyanka Patel
Affiliation:Department of Pharmacology, SSR College of Pharmacy, Silvassa, Department of Pharmaceutics, SSR College of Pharmacy, Silvassa, Department of Pharmacology, SSR College of Pharmacy, Silvassa
Keywords:Antibiotic, antimicrobial resistance, efflux pump, inhibitors, antimicrobial adjuvant, β-lactamase.
Abstract:Antibiotic resistance is one of the most prevalent, complex and serious global health issues,
and needs to be monitored and controlled with medicine. Many approaches have been used to
reduce the emergence and impact of resistance to antibiotics. The antimicrobial adjuvant approach
is considered as novel, more effective and less expensive. The said approach not only suppresses
the emergence of resistance but also conserves the activity of existing antibiotics by offering a
promising strategy that is also complementary to the discovery of new antibiotics. This review contains
an outline of the basic types of antibiotic adjuvant, their structure, the basis of their operation,
their substrate antibiotics and the challenges in this field, as well as the role of potential compounds,
namely β-lactamase inhibitors, efflux pump inhibitors and permeability enhancers in antibiotic
resistance and their possible solutions.
