A Review on the Synthesis and Biological Studies of 2,4-Thiazolidinedione Derivatives

Author(s): Srinivasa Reddy Bireddy*, Veera Swamy Konkala, Chandraiah Godugu, Pramod Kumar Dubey

Journal Name: Mini-Reviews in Organic Chemistry

Volume 17 , Issue 8 , 2020

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Abstract:

2,4-Thiazolidinediones are versatile scaffolds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. This review deals with the synthesis of various bio-active 2,4-thiazolidinedione derivatives. It is presented on the basis of the linker variations at 3rd & 5th positions of 2,4-thizolidinediones. Biological evaluations of various derivatives thus prepared and toxicity studies on the respective products as given by various researchers/ Research groups have been described.

Keywords: 2, 4-Thiazolidinediones, antidiabetic activity, glitazones, Knoevenagel condensation, acid hydrolysis, type-2 diabetes.

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Article Details

VOLUME: 17
ISSUE: 8
Year: 2020
Published on: 24 December, 2020
Page: [958 - 974]
Pages: 17
DOI: 10.2174/1570193X17666200221123633
Price: $65

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