2,4-Thiazolidinediones are versatile scaffolds with a unique structural feature of hydrogen
bonding donor and the hydrogen bonding acceptor region. This review deals with the synthesis of
various bio-active 2,4-thiazolidinedione derivatives. It is presented on the basis of the linker variations
at 3rd & 5th positions of 2,4-thizolidinediones. Biological evaluations of various derivatives thus
prepared and toxicity studies on the respective products as given by various researchers/ Research
groups have been described.
Keywords: 2, 4-Thiazolidinediones, antidiabetic activity, glitazones, Knoevenagel condensation, acid hydrolysis, type-2 diabetes.
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