Background: The high molecular weight and increasing lipophilicity of drug
face many problems starting from the drug development to formulation and conduction of
pharmacological, toxicological and pharmacokinetic studies to its biological application.
To overcome this problem, nano-sized formulations are in trend recently. The use of Solid
lipid nanoparticles (SLNs) offers new insight into the formulation of the poor soluble and
low bioavailable drug.
Objective: The study aimed to investigate the literature concerning the development of
SLNs for oral drug delivery of poorly soluble drugs, with a view survey the various methods
of manufacturing and evaluation of formulation of SLNs and future prospects of SLNs
and application of SLNs in oral delivery systems.
Conclusion: Oral drug delivery is looking ahead progressively into newer directions due
to the realization of various poor performance limiting factors such as reduced drug solubility
or absorption, rapid metabolism, high actuation in plasma level of drug and variability
caused due to food effect. These play a vital role in disappointing in vivo results, which
leads in the failure of the conventional delivery system. Since the last decade, oral drug
delivery has taken a new dimension with the increasing application of SLNs as a carrier
for the delivery of poorly water-soluble or lipophilic drugs. The site-specific and sustained
release effect of the drug is better achieved by using SLNs. This review highlights the various
pros and cons, manufacturing techniques, characterization, and future prospects of
SLNs in oral drug delivery systems.