Δα,β-Butenolides [Furan-2(5H)-ones]: Ring Construction Approaches and Biological Aspects - A Mini-Review

Author(s): Andrés-Felipe Villamizar-Mogotocoro, Andrés-Felipe León-Rojas, Juan-Manuel Urbina-González*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 17 , Issue 8 , 2020

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Abstract:

The five-membered oxacyclic system of furan-2(5H)-ones, commonly named as γ- butenolides or appropriately as Δα,β-butenolides, is of high interest since many studies have proven its bioactivity. During the past few years, Δα,β-butenolides have been important synthetic targets, with several reports of new procedures for their construction. A short compendium of the main different synthetic methodologies focused on the Δα,β-butenolide ring formation, along with selected examples of compounds with relevant biological activities of these promising pharmaceutical entities is presented.

Keywords: Δα, β-butenolide, butenolactone, furan-2(5H)-one, isocrotonolactone, unsaturated γ lactone, γ-butenolide.

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Article Details

VOLUME: 17
ISSUE: 8
Year: 2020
Published on: 24 December, 2020
Page: [922 - 945]
Pages: 24
DOI: 10.2174/1570193X17666200220130735
Price: $65

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