Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes

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Author(s): Christos Damaskos*, Alexandros Litos, Dimitrios Dimitroulis, Efstathios A. Antoniou, Dimitrios Mantas, Konstantinos Kontzoglou, Nikolaos Garmpis

Journal Name: Current Cardiology Reviews

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Introduction: Cardiovascular, together with renal disease, claims a significant proportion of morbidity and mortality in association with type 2 diabetes mellitus (T2DM) and obesity. To improve on the long-term renal and cardiovascular outcome, there is the incorporation of bariatric surgery (BS), which seems to be a pivotal intervention.

Areas explored: Cohort studies and randomized controlled trial (RCT) research of BS among patients with T2DM, are investigated by screening, then information on renal effects and cardiovascular outcome gathered. Metabolic surgery (MS) and BS reduce both mortality and the risk of cardiovascular disorder, chronic kidney diseases and albuminuria. MS refers to a surgical approach whose primary intent is the control of metabolic alterations/hyperglycemia in contrast to BS which is a mere weight-reduction therapy. Patients suffering from poor glycaemic control and other macro and micro-vascular diseases will benefit from a surgical approach. The approach implicates hypertension glomerular remission, gut microbiota shift, reduced renal inflammation and fewer instances of chronic cardiac remodelling.

Conclusion: MS is beneficial where the main aim is to attain a significant and long-lasting weight loss results. The RCTs have depicted the superiority which surgical mechanisms hold over medically based therapy, for enhancing glycaemic control, and achieving remission of diabetes. This type of surgery improves life quality, reduces incidences of other obesity and diabetes relating diseases like microvascular illness, sleep apnea, fatal disorder, and fatty liver disease.

Keywords: Cardiovascular, Metabolic surgery, Obesity, Type 2 diabetes, Bariatric, procedures

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(E-pub Ahead of Print)
DOI: 10.2174/1573403X16666200220120226
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