Limitations on the pharmacotherapy and a high prevalence worldwide are critical issues related to
depression and cancer. It has been discussed that a dysregulation of intracellular Ca2+ homeostasis is involved in
the pathogenesis of both these diseases. In addition, depression raises the risk of cancer incidence. Consistent
data support the concept that depression is an independent risk issue for cancer. However, the cellular mechanisms
involved in this link between depression and cancer remain uncertain. Considering our previous reports
about Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling), I herein discussed the putative contribution
of Ca2+/cAMP signalling in this link between depression and cancer. Moreover, it is important to take depression
into account during the process of prevention and treatment of cancer.
Keywords: Depression, cancer, Ca2+/cAMP signaling, homeostasis, pharmacotherapy, homeostasis.
Fujita, M.; Richards, E.M. cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor. Mol. Psychiatry, 2017, 22(5), 754-759.
Bergantin, L.B.; Caricati-Neto, A. The “Calcium Paradox” and its Impact on Neurological and Psychiatric Diseases; Cambridge Scholars Publishing: UK, 2018.
Bergantin, L.B. Diabetes and cancer: Debating the link through Ca2+/cAMP signalling. Cancer Lett., 2019, 448, 128-131.
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