A Review on Opuntia Species and its Chemistry, Pharmacognosy, Pharmacology and Bioapplications

Author(s): Dharmendra Kumar*, Pramod K. Sharma

Journal Name: Current Nutrition & Food Science

Volume 16 , Issue 8 , 2020


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Background: Opuntia species, locally known as prickly pear was used for various purposes as food, medicine, beverage, source of dye and animal food. Many studies have revealed its pharmacology activity from time to time. This review is a collection of chemistry, pharmacognosy, pharmacology and bioapplications of the cactus family.

Methods: Many sources were used to collect information about Opuntia species such as Pub med, Google scholar, Agris, science direct, Embase, Merk index, Wiley online library, books and other reliable sources. This review contains studies from 1812 to 2019.

Results: The plants from the cactus family offer various pharmacological active compounds including phenolic compounds, carotenoids, betalains, vitamins, steroids, sugar, amino acids, minerals and fibers. These bioactive compounds serve various pharmacological activities such as anticancer, antiviral, anti-diabetic, Neuroprotective, anti-inflammatory, antioxidant, Hepatoprotective, antibacterial, antiulcer and alcohol hangover. According to various studies, Opuntia species offer many bioapplications such as fodder for animal, soil erosion, prevention, human consumption and waste water decontamination. Finally, different parts of plants are used in various formulations that offer many biotechnology applications.

Conclusion: Different parts of Opuntia plant (fruits, seeds, flowers and cladodes) are used in various health problems which include wound healing, anti-inflammatory and urinary tract infection from ancient times. Nowadays, researches have extended several pharmacological and therapeutic uses of Opuntia species as discussed in this review. Many in-vitro and in-vivo models are also discussed in this review as the proofs of research findings. Various research gaps have been observed in current studies that require attention in the future.

Keywords: Bioapplications, cactus, opuntia species, pharmacology, phytochemical, prickly pear, toxicity, traditional uses.

[1]
Miller P. The Gardener’s Dictionary Vol. 2. London: John & James Rivington 1754; Retrieved 2019-07-01.
[2]
Damasceno GAB, Silva RMACV, Fernandes JM, Ostrosky EA, Langassner SMZ, Ferrari M. Use of Opuntia ficus-indica (L.) Mill extracts from Brazilian Caatinga as an alternative of natural moisturizer in cosmetic formulations. Braz J Pharm Sci 2016; 52: 459-70.
[http://dx.doi.org/10.1590/s1984-82502016000300012]
[3]
Nallakurumban B, Suja N. kumar VA, Pushpa G, Geetha PS. Study on phytochemical and antioxidant properties of water apple (Syzygium aqueum) and Chappathikalli (Opuntia ficus-indica). Int J Res Emerg Sci Technol 2015; 2(10): 18-23.
[4]
Pawar AV, Killedar SG, Dhuri VG. Opauntia: medicinal Plant IJARIIT 2017; 148-54.
[5]
Felice MS. Prickly pear cactus, Opuntia spp. A spine-tingling tale. Weed Technol 2004; 18(3): 869-77.
[http://dx.doi.org/10.1614/WT-04-134]
[6]
Chauhan SP, Sheth NR, Jivani NP, Rathod IS, Shah PI. Biological actions of Opuntia species. Syst Rev Pharm 2010; 1(2): 146-51.
[http://dx.doi.org/10.4103/0975-8453.75064]
[7]
Stock AD, Hussey N, Beckstom MD. A new species of Opuntia (Cactaceae) from Mojave Co, Arizona. Cactus Succul J 2014; 86(2): 79-83.
[http://dx.doi.org/10.2985/015.086.0201]
[8]
Mauseth JD. Structure-function relationships in highly modified shoots of cactaceae. Ann Bot 2006; 98(5): 901-26.
[http://dx.doi.org/10.1093/aob/mcl133] [PMID: 16820405]
[9]
Louis ST. Reports of the officers of the toard. Twenty First Annual Report Boards of Trustees 2019; 21: 1-195.
[10]
Parsons HG. The delicious fruits of actinidia. J NY Botan Garden 1917; 216: 1-44.
[11]
Ortiz DG, Lumbreras EL, Pujol JL. Opuntia ficus-indica ‘Anacantha’ and ‘Vertex’, first references as cultivated plants in Spain and Europe. Bouteloua 2014; 19: 129-40.
[12]
Henderson L. Alien weeds and invasive plants. In: In: A complete guide to declared weeds and invaders in South Africa Plant Protection Research Institute Handbook No 12 PPR, ARC South Africa. 2001; p. 300.
[13]
Engelmann G. Opuntia erinacea. Proc Am Acad Arts Sci 1856; 8: 301.
[14]
Hunt DR. Opuntia articulate. Bradleya 2019; 15: 93.
[15]
Duarte W, Oakley L, Pin A. Opuntia elata The IUCN Red List of Threatened Species 2013. Available from: www.iucnredlist.org
[16]
Hosking JR, Mcfadyen RE, Murray ND. Distribution and biological control of cactus species in Eastern Australia. Plant Protect Quart 1988; 3: 115-23.
[17]
Baxter EM. Opuntia aurea, a new species Cact Succ Soc Am J 1933 Dec; 489-90.
[18]
Heil KD, Brack S. The cacti of big bend national park. Cact Succ J 1986; 60: 17-34.
[19]
Powell AM, Weedin JF. Cacti of the Trans-Pecos & Adjacent Areas. USA: Texas Tech University Press 2004.
[20]
Engelmann D. Cereus engelmannii Parry ex Engelmann. Amer J Sci Arts 1852; 2(14): 338.
[21]
Washington DC. Contributions from the United States National Herbarium, Smithsonian Institution Press, 12, 402. Contributions from the United States National Herbarium 1890.
[22]
Britton NL, Rose JN. The Cactaceae. USA: Dover Publications 1920.
[23]
Griffiths H. Opuntia cacanapa. New Mexico Agric Exp Station: Bull 1906; 60: 47-8.
[24]
Engelmann D, Bigelow . Proc Am Acad Arts Sci 1857; 3: 293.
[25]
Louis S. Opuntia canada. Annual Report Missouri Botanical Garden 1909; 20: 90-1.
[26]
Majure LC, Ervin GN. The Opuntias of Mississippi. Haseltonia 2007; 14: 111-26.
[http://dx.doi.org/10.2985/1070-0048-14.1.111]
[27]
Clokey IW. Notes on the flora of the Charleston Mountains, Clark County, Nevada. V. Cactaceae. Madrono 1943; 7: 67-76.
[28]
Villasenor JL. Checklist of the native vascular plants of Mexico. Revista Mexicana de Biodiversidad 2016; 87: 559-902.
[29]
Engelmann G, Bigelow . Proc Am Acad Arts Sci 1856; 3: 291.
[30]
Ferguson A. Opuntia chisosensis. Cactus Succ J 1986; 58(3): 124.
[31]
Engelmann D. Memoir of a tour to Northern Mexico Connected with Col Doniphan's Expedition Washington: Tippin and Streepers. 1848; p. 95.
[32]
Britton NL, Rose JN. The Cactaceae, Descriptions and Illustrations of Plants of the Cactus Family. Washington: Carnegie Institution of Washington 1919.
[33]
Griffiths D. Additional species of Opuntia. Bull Torrey Botan Club 1916; 43: 523.
[34]
Griffiths D. Opuntia confusa. Proc Biol Soc Washington 1914; 27(6): 28.
[35]
Britton R. Opuntioideae of North America. Smithsonian Miscellaneous Collections 1908; 50: 532-3.
[36]
Griffiths D. New species of Opuntia. Bull Torrey Botan Club 2019; 43: 88.
[37]
Engelmann D, Bigelow JM. Opuntia cyclodes. Proc Amer Acad Arts 1856; 3: 291.
[38]
Engelmann G. Four hundred and twenty-eight meeting. Annual Meeting; Synopsis of the Cactaceæ of the Territory of the United States and Adjacent Regions. Proc Am Acad Arts Sci 1856; 3: 256-314.
[http://dx.doi.org/10.2307/20021194]
[39]
Szutorisz G. A new Opuntia species. Opuntia debreczyi species nova (Cactaceae) from the United States of America. Hungarian Periodical Kaktusz-VilAg XXVI 2002; 4: 115-7.
[40]
Brolin K. Impact on plant diversity of introduced Opuntia stricta in Southern Madagascar, minor field studies. International Office Swedish University of Agricultural Sciences 2004; 287: 23.
[41]
Griffiths D. Annual Report of the Missouri Botanical Garden, Illustrated studies in the genus Opuntia 1908; 19: 266.
[42]
Engelmann D, Bigelow JM. Opuntia echinocarpa var. major. Proc Am Acad Arts Sci 1856; 3: 305.
[43]
Porter DM. Vascular Plants of the Galapagos: origins and dispersal. In: Patterns of evolution in Galápagos organisms. San Francisco, California: Pacific Division, AAAS 1983; pp. 33-96.
[44]
Dyck SR, Ignaz JFMAH, Altgraf FU. Hortus dyckensis: ou catalogue des plantes cultivées dans les jardins de Dyck. Dusseldorf Arnz 1861; p. 408.
[45]
Deshpande VG. Eradication of prickly pear by cochineal insects in the Bombay presidency. Agric Live-stock India 1935; 5(1): 36-42.
[46]
Salm-Dyck Engelmann. Planta lindheimeriana Boston J Nat History 1850; 6(2): 207-8.
[47]
Britton NL, Rose JN. The cactaceae, description and illustrations of plants of the cactus family. Carnegie Inst Washington 1919; 3: 227.
[48]
Heliot Z, Gerardo C, Michael AS. Mammalian Species No 725. USA: American Society of MammaIogists 2003; pp. 1-4.
[49]
Janik J, Paul RE. The encyclopedia of fruits and nuts Wallingford, UK: CABI, XVIII. 2008.
[50]
Haworth AH. Opuntia fragilis. In: Supplementum plantarum succulentarum Londini. Impensis J. Harding 1819; p. 82.
[51]
Hemsley, botting W. Opuntia galapageia Hemsl. Mag Zool Bot 1837; 1: 467.
[52]
Griffiths Hare G. Opuntia santa rita. Smithsonian Misc Collect 1909; 52: 195.
[53]
Rafinesque CS. Opuntia, Medical flora, or, Manual of the medical botany of the United States of North America 1830; 247-8.
[54]
Anderson EF. Grusonia invicta. Cact Succ J (Los Angeles) 2019; 71(6): 325.
[55]
Coulter JM, Benson LD. Opuntia phaeacantha. Contributions from the US National Herbarium 1896; 3: 419.
[56]
Candolle AP. Opuntia leucotricha. Mémoires du Muséum d’Histoire Naturelle 2019; 17: 119.
[57]
Engelmann D. Opuntia lindheimeri. Boston J Nat History 2019; 6: 207.
[58]
Bruce D, Parfitt DJ, Pinkava M. Nomenclatural and systematic reassessment of Opuntia engelmannii and O. lindheimeri. JSTOR 1988; 35(4): 342-9. [cactaceae]
[59]
Opuntia longispina. Cactus Paris 2019; 38: 250.
[60]
Engelmann D. Opuntia macrocentra. Proc Am Acad Arts Sci 1856; 3: 292.
[61]
Engelmann D. Opuntia macrorhiza. Boston J Nat History 1850; 6: 206.
[62]
Villasenor JL. Checklist of the native vascular plants of Mexico. Revista Mexicana de Mex Biodiversidad 2016; 87: 559-902.
[63]
Warren E. Opuntia monacantha, the prickly pear pest. Agric JS Africa 1914; 7(3): 387-91.
[64]
Benson LD. Opuntia nicholii, The Cacti of Arizona edition. USA. The University of Arizona Press 1950; 2: 48.
[65]
Philbrick RN. Opuntia oricola. Cactus Succ J (US) 2019; 36(6): 163.
[66]
Weingart W. Monatsschrift der Deutschen Kakteen-Gesellschaft 1929; 9: 167-9.
[67]
Parfitt BD. Opuntia pinkavae, (cactaceae) a new species from arizona and Utah. Rhodora 1997; 99: 899.
[68]
Haworth AH. Opuntia polyacantha. Suppl Plant Succ 1819; 82: 224.
[69]
Britton NL, Rose JN. The Cactaceae: descriptions and illustrations of plants of the Cactus family Washington, DC: Gibson Brother Press, Carnegie Institution of Washington. 2019; 248: pp. 100-.
[70]
Haworth AH. Icosandria Monog. Opuntia. Synopsis Plant Succ 1812; p. 195.
[71]
Wendl JC. Opuntia robusta. Cat Hort Herrenh 1835; 112: 75-6.
[72]
Engelmann B. Opuntia rufida. Proc Am Acad Arts Sci 1856; 8: 2985.
[73]
Berger A. Opuntia schumannii Anales Mus Nac Buenos Aires ser 1905; 3(40): 511.
[74]
Britton NL. The Cactaceae, descriptions and illustrations of plants of the cactus family. Washington: Carnegie Institution of Washington 1919; pp. 134-5.
[75]
Engelmann G. Opuntia stenopetala. Proc Am Acad Arts Sci 1856; 3: 289.
[76]
Haworth AH. Icosandria monog, Opuntia. Synopsis Plant Succ 1812; p. 191.
[77]
Aragon GA. Cactaceas de los alrededores de la ciudad de Arequipa. Bol Lima 1982; 20(4): 59-69. [prim
[78]
Iliff J. The andean opuntias: an annotated checklist of the indigenous non-platyopuntioid Opuntias (Cactaceae - Opuntioideae) of South Americ. Succ Pl Res 2012; 6: 234.
[79]
Hernandez HM, Gomez-Hinostrosa C. Studies on Mexican Cacraceae. IV, A new subspecies of Echinocereus palmeri Britton & Rose, first record of the species in the Chihuahuan Desert. Bradleya 2004; 22: 1-8.
[http://dx.doi.org/10.25223/brad.n22.2004.a1]
[80]
Bruce DP, Arthur CG. Cactaceae Jussieu. Flora North Am 2019; 4: 92-4.
[81]
Engelmann G, Louis ST, John M, Bigelow JM. Description of the Cactaceae The Botany of the Expedition 1856; 1-62.
[82]
Kalungia AC, Mataka M, Kanonga P, Bwalya AG, Prasar L, Munkombwe D. Opuntia stricta cladode extract reduces blood glucose levels in alloxan-induced diabetic mice. Int J Diabetes Res 2018; 7(1): 1-11.
[83]
Ghazi Z, Ramdani M, Fauconnier ML. Mahi BEl, Cheikh R. Fatty acids sterols and vitamin E composition of seed oil of Opuntia ficus indica and Opuntia dillenii from Morocco. J Mater Environ Sci 2013; 4(6): 967-72.
[84]
Ali RFM, Abou-Elella FM. Antioxidant and anticancer activities of different constituents extracted from Egyptian prickly pear cactus (Opuntia ficus-indica) peel. Biochem Anal Biochem 2014; 3: 158.
[85]
Kim JW, Kim TB, Yang H, Sang HS. Phenolic compounds isolated from Opuntia ficus-indica fruits. Nat Prod Sci 2016; 22(2): 117-21.
[http://dx.doi.org/10.20307/nps.2016.22.2.117]
[86]
Mabrouki L, Zougari B, Bendhifi M, Borgi MA. Evaluation of antioxidant capacity, phenol and flavonoid contents of Opuntia streptacantha and Opuntia ficus indica fruits pulp Nature & Technologie 2014; 02-8.
[87]
Diaz Medina EM, Rodriguez-Rodriguez EM, Diaz Romero C. Chemical characterization of Opuntia dillenii and Opuntia ficus-indica fruits. J Food Chem 2007; 103: 38-45.
[http://dx.doi.org/10.1016/j.foodchem.2006.06.064]
[88]
Fernández-López JA, Almela L, Obón JM, Castellar R. Determination of antioxidant constituents in cactus pear fruits. Plant Foods Hum Nutr 2010; 65(3): 253-9.
[http://dx.doi.org/10.1007/s11130-010-0189-x] [PMID: 20811778]
[89]
Dib H, Belarbi M, Beghdad MC, Seladji M. Antioxidant activity of Opuntia ficus-indica flowers phenolic extracts. Int J Pharm Sci Res 2014; 5(10): 4574-82.
[90]
Alimi H, Hfaiedh N, Bouoni Z, Sakly M, Ben Rhouma K. Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats. Environ Toxicol Pharmacol 2011; 32(3): 406-16.
[http://dx.doi.org/10.1016/j.etap.2011.08.007] [PMID: 22004960]
[91]
Allai L, Mosrafa K, Amiri BEI, Ozturk M. Evaluation of antioxidant activity and phenolic composition of Opuntia ficus-indica cladodes collected from Moroccan Settat Region. Eurasian J Anal Chem 2007; 12(1): 105-17.
[92]
Slimen IB, Najar T, Abderrabba M. Opuntia ficus indica as a source of bioactive and nutritional phytochemicals. J Food Nutr Sci 2016; 4: 162-9.
[93]
Cano MP, Gómez-Maqueo A, García-Cayuela T, Welti-Chanes J. Characterization of carotenoid profile of Spanish Sanguinos and Verdal prickly pear (Opuntia ficus-indica, spp.) tissues. Food Chem 2017; 237: 612-22.
[http://dx.doi.org/10.1016/j.foodchem.2017.05.135] [PMID: 28764043]
[94]
Aman R, Carle R, Conrad J, Beifuss U, Schieber A. Isolation of carotenoids from plant materials and dietary supplements by high-speed counter-current chromatography. J Chromatogr A 2005; 1074(1-2): 99-105.
[http://dx.doi.org/10.1016/j.chroma.2005.03.055] [PMID: 15941044]
[95]
Leopoldo GC, Santiago FK, Arturo BPL, Norma GV, Aurea BN. Carotenoid content, antioxidant activity and sensory evaluation of low-calorie nopal (Opuntia ficus-indica) marmalade. J Food Process Preserv 2011; 36: 267-75.
[http://dx.doi.org/10.1111/j.1745-4549.2011.00589.x]
[96]
Nadia C, Hayette L, Safia M, Yasmina M, Yasmina H, Tamendjari A. Physico-chemical characterisation and antioxidant activity of some Opuntia ficus-indica varieties grown in North Algeria. Afr J Biotechnol 2013; 12(3): 299-307.
[http://dx.doi.org/10.5897/AJB12.1946]
[97]
Kuti OJ. Antioxidant compounds from four Opuntia cactus pear fruit varieties. Food Chem 2004; 85: 527-33.
[http://dx.doi.org/10.1016/S0308-8146(03)00184-5]
[98]
Chauhan SP, Sheth NR, Rathod IS, Suhagia BN, Maradia RB. Analysis of betalins from fruits of Opuntia species. Phytochem Rev 2013; 12: 35-45.
[http://dx.doi.org/10.1007/s11101-012-9248-2]
[99]
Albano C, Negro C, Tommasi N, et al. Betalains, phenols and antioxidant capacity in cactus pear [Opuntia ficus-indica (L.) Mill.] fruits from apulia (South Italy) genotypes. Antioxidants 2015; 4(2): 269-80.
[http://dx.doi.org/10.3390/antiox4020269] [PMID: 26783704]
[100]
Fernández-López JA, Castellar R, Obón JM, Almela L. Monitoring by liquid chromatography coupled to mass spectrometry the impact of pH and temperature on the pigment pattern of cactus pear fruit extracts. J Chromatogr Sci 2007; 45(3): 120-5.
[http://dx.doi.org/10.1093/chromsci/45.3.120] [PMID: 17462125]
[101]
Stintzing FC, Schieber A, Carle R. Identification of betalains from yellow beet (Beta vulgaris L.) and cactus pear [Opuntia ficus-indica (L.) Mill.] by high-performance liquid chromatography-electrospray ionization mass spectrometry. J Agric Food Chem 2002; 50(8): 2302-7.
[http://dx.doi.org/10.1021/jf011305f] [PMID: 11929288]
[102]
Evelyn RR, Juan Rogelio AR, Marco Martin GC, Roberto SS, Fidel MG, Juarez-Flores BI. Assessment of extraction methods and biological value of seed oil from eight variants of prickly pear fruit opuntia spp. Waste Biomass Valoriz 2020; 11: 1181-9.
[103]
Ali M, Sultana S, Mir SR. Isolation of sterols, triterpenoids and a sesquaterpene from the leaves of Ficus nitida Thunb. Int J Pharma Chem Res 2017; 3(2): 190-5.
[104]
Jiang J, Li Y, Chen Z, Min Z, Lou F. Two novel C29-5-sterols from the stems of Opuntia dillenii. Steroids 2006; 71: 1073-7.
[105]
Dick M, Dal Magro L, Rodrigues RC, Rios AO, Flôres SH. Valorization of Opuntia monacantha (Willd.) Haw. cladodes to obtain a mucilage with hydrocolloid features: physicochemical and functional performance. Int J Biol Macromol 2019; 123: 900-9.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.11.126] [PMID: 30447373]
[106]
Salehi E, Emam-Djomeh Z, Askari G, Fathi M. Opuntia ficus indica fruit gum: extraction, characterization, antioxidant activity and functional properties. Carbohydr Polym 2019; 206: 565-72.
[http://dx.doi.org/10.1016/j.carbpol.2018.11.035] [PMID: 30553358]
[107]
Bouaouine O, Bourven I, Khalil F, Bressollier PB. Identification and role of Opuntia ficus indica constituents in the flocculation mechanism of colloidal solutions. Separ Purif Tech 2019; 209: 892-9.
[http://dx.doi.org/10.1016/j.seppur.2018.09.036]
[108]
El Kossori RL, Villaume C, El Boustani E, Sauvaire Y, Méjean L. Composition of pulp, skin and seeds of prickly pears fruit (Opuntia ficus indica sp.). Plant Foods Hum Nutr 1998; 52(3): 263-70.
[http://dx.doi.org/10.1023/A:1008000232406] [PMID: 9950087]
[109]
Stintzing FC, Schieber A, Carle R. Amino acid composition and betaxanthin formation in fruits from Opuntia ficus-indica. Planta Med 1999; 65(7): 632-5.
[http://dx.doi.org/10.1055/s-1999-14037] [PMID: 17260288]
[110]
Amadi BA, Njoku UC, Agumuo EN, Amadi PU, Ezendiokwere OE, Nwauche KT. Assessment of vitamins, protein quality and mineral bioavailability of matured stems of Opuntia dillenii grown in Nigeria. Bioengin Biosci 2017; 5(3): 47-54.
[111]
Aguilera-Barreiro Mde L, Rivera-Márquez JA, Trujillo-Arriaga HM, et al. Intake of dehydrated nopal (Opuntia ficus indica) improves bone mineral density and calciuria in adult Mexican women. Food Nutr Res 2013; 57: 57.
[http://dx.doi.org/10.3402/fnr.v57i0.19106] [PMID: 23704856]
[112]
Molina IR, Cortez EG, Bah M, et al. Characterization of calcium compounds in Opuntia ficus indica as a source of calcium for human diet. J Chem 2015; 2015710328
[http://dx.doi.org/10.1155/2015/710328]
[113]
Kang J, Park J, Choi SH, Igawa S, Song Y. Opuntia humifusa supplementation increased bone density by regulating parathyroid hormone and osteocalcin in male growing rats. Int J Mol Sci 2012; 13(6): 6747-56.
[http://dx.doi.org/10.3390/ijms13066747] [PMID: 22837661]
[114]
Ko BS, Lee HW, Kim DS, Kang S, Ryuk JA, Park S. Supplementing with Opuntia ficus-indica Mill and Dioscorea nipponica Makino extracts synergistically attenuates menopausal symptoms in estrogen-deficient rats. J Ethnopharmacol 2014; 155(1): 267-76.
[http://dx.doi.org/10.1016/j.jep.2014.05.020] [PMID: 24875644]
[115]
Bensadón S, Hervert-Hernández D, Sáyago-Ayerdi SG, Goñi I. By-products of Opuntia ficus-indica as a source of antioxidant dietary fiber. Plant Foods Hum Nutr 2010; 65(3): 210-6.
[http://dx.doi.org/10.1007/s11130-010-0176-2] [PMID: 20623195]
[116]
Manai F, Ammar M, Yanez JG, Elaloui E, Moussaoui Y. Cellulose fibre from Tunisian barbary fig “Opuntia ficus-indica” for papermaking. Cellulose 2016; 23(3): 2061-72.
[http://dx.doi.org/10.1007/s10570-016-0899-9]
[117]
Vieyra H, Figueroa-Lopez U, Guevara-Morales A, Vergara-Porras B, Martin-Martinez ES, Aguilar-Mendez MA. Optimized monitoring of production of cellulose nanowhiskers from Opuntia ficus-indica (Nopal Cactus). Int J Polym Sci 2015; 2015871345
[http://dx.doi.org/10.1155/2015/871345]
[118]
Greco A, Gennaro R, Timo A, Bonfantini F, Maffezoli A. A comparative STUDY berween bio-composite obtained with Opuntia ficus indica cladodes and flax fibres. J Polym Environ 2013; 21: 910-6.
[119]
Grube B, Chong PW, Lau KZ, Orzechowski HD. A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study. Obesity (Silver Spring) 2013; 21(1): 58-64.
[http://dx.doi.org/10.1002/oby.20244] [PMID: 23505169]
[120]
Uebelhack R, Busch R, Alt F, Beah ZM, Chong PW. Effects of cactus fiber on the excretion of dietary fat in healthy subjects: a double blind, randomized, placebo-controlled, crossover clinical investigation. Curr Ther Res Clin Exp 2014; 76: 39-44.
[http://dx.doi.org/10.1016/j.curtheres.2014.02.001] [PMID: 25067985]
[121]
Galati EM, Monforte MT, Tripodo MM, d’Aquino A, Mondello MR. Antiulcer activity of Opuntia ficus indica (L.) Mill. (Cactaceae): ultrastructural study. J Ethnopharmacol 2001; 76(1): 1-9.
[http://dx.doi.org/10.1016/S0378-8741(01)00196-9] [PMID: 11378276]
[122]
Galati EM, Mondello MR, Giuffrida D, et al. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. J Agric Food Chem 2003; 51(17): 4903-8.
[http://dx.doi.org/10.1021/jf030123d] [PMID: 12903943]
[123]
Alimi H, Hfaiedh N, Bouoni Z, et al. Antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis root extract in rats. Phytomedicine 2010; 17(14): 1120-6.
[http://dx.doi.org/10.1016/j.phymed.2010.05.001] [PMID: 20638261]
[124]
Trachtenberg S, Mayer AM. Composition and properties of Opuntia ficus indica mucilage. Phytochemistry 1981; 20: 2665-8.
[http://dx.doi.org/10.1016/0031-9422(81)85263-6]
[125]
Galati EM, Pergolizzi S, Miceli N, Monforte MT, Tripodo MM. Study on the increment of the production of gastric mucus in rats treated with Opuntia ficus indica (L.) Mill. cladodes. J Ethnopharmacol 2002; 83(3): 229-33.
[http://dx.doi.org/10.1016/S0378-8741(02)00243-X] [PMID: 12426090]
[126]
Park EH, Kahng JH, Paek EA. Studies on the pharmacological action of cactus: identification of its anti-inflammatory effect. Arch Pharm Res 1998; 21(1): 30-4.
[http://dx.doi.org/10.1007/BF03216749] [PMID: 9875511]
[127]
Park EH, Kahng JH, Lee SH, Shin KH. An anti-inflammatory principle from cactus. Fitoterapia 2001; 72(3): 288-90.
[http://dx.doi.org/10.1016/S0367-326X(00)00287-2] [PMID: 11295308]
[128]
Dok-Go H, Lee KH, Kim HJ, et al. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res 2003; 965(1-2): 130-6.
[http://dx.doi.org/10.1016/S0006-8993(02)04150-1] [PMID: 12591129]
[129]
Slimen IB, Najar T, Abderrabba M. Opuntia ficus indica a source of bioactive and nutritional phytochemicals. J Food Nutr Sci 2016; 4(6): 162-9.
[130]
Maataoui SB, Maataoui RB, Almesrar B, Hilali S. Anti ulcer activity of prickly pear (Opuntia ficus indica) cladodes extracts. Int J Adv Res (Indore) 2018; 6(11): 498-506.
[http://dx.doi.org/10.21474/IJAR01/8023]
[131]
Trombetta D, Puglia C, Perri D, et al. Effect of polysaccharides from Opuntia ficus-indica (L.) cladodes on the healing of dermal wounds in the rat. Phytomedicine 2006; 13(5): 352-8.
[http://dx.doi.org/10.1016/j.phymed.2005.06.006] [PMID: 16635743]
[132]
Mohamed RA. Malah MMEl, Ramadan RS. Effect of watery juice of aloe vera and Opuntia ficus leaves on gastric acid secretion and healing of acute gastric ulcer in rats. J Am Sci 2010; 6(10): 600-5.
[133]
Ammar I, Salem MB, Harrabi B, et al. Anti-inflammatory activity and phenolic composition of prickly pear (Opuntia ficus-indica) flowers. Ind Crops Prod 2018; 12: 313-9.
[http://dx.doi.org/10.1016/j.indcrop.2017.12.028]
[134]
Matias A, Nunes SL, Poejo J, et al. Antioxidant and anti-inflammatory activity of a flavonoid-rich concentrate recovered from Opuntia ficus-indica juice. Food Funct 2014; 5(12): 3269-80.
[http://dx.doi.org/10.1039/C4FO00071D] [PMID: 25347222]
[135]
Chahdoura H, Adouni K, Khlifi A, et al. Hepatoprotective effect of Opuntia microdasys (Lehm.) Pfeiff flowers against diabetes type II induced in rats. Biomed Pharmacother 2017; 94: 79-87.
[http://dx.doi.org/10.1016/j.biopha.2017.07.093] [PMID: 28755576]
[136]
Cho JY, Park SC, Kim TW, et al. Radical scavenging and anti-inflammatory activity of extracts from Opuntia humifusa Raf. J Pharm Pharmacol 2006; 58(1): 113-9.
[http://dx.doi.org/10.1211/jpp.58.1.0014] [PMID: 16393471]
[137]
Kumar GP, Khanum F. Neuroprotective potential of phytochemicals. Pharmacogn Rev 2012; 6(12): 81-90.
[http://dx.doi.org/10.4103/0973-7847.99898] [PMID: 23055633]
[138]
Dok-Go H, Lee KH, Kim HJ, et al. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3 methyl ether, isolated from Opuntia ficus-indica var. Saboten Brain Res 2003; 965(1-2): 130-6.
[139]
Cho J, Han CK, Lee YS, Jin C. Neuroprotective and antioxidant effects of the butanol fraction prepared from Opuntia ficus-indica var. saboten. J Appl Pharmacol 2007; 15: 205-11.
[http://dx.doi.org/10.4062/biomolther.2007.15.4.205]
[140]
Jung SY, Kim HJ, Lee J, Cho J, Lee YS, Jin C. Neuroprotective effects of quercetin 3-O-methyl ether, quercetin and (±)-dihydroquercetin in a rat model of transient focal cerebral ischemia. Bull Korean Chem 2012; 33: 2443-6.
[http://dx.doi.org/10.5012/bkcs.2012.33.7.2443]
[141]
Chen Y, Zhao B, Huang X, et al. Purification and neuroprotective effects of polysaccharides from Opuntia Milpa Alta in cultured cortical neurons. Int J Biol Macromol 2011; 49(4): 681-7.
[http://dx.doi.org/10.1016/j.ijbiomac.2011.06.031] [PMID: 21763720]
[142]
Sreekanth D, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P. Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia cell line-K562. Phytomedicine 2007; 14(11): 739-46.
[http://dx.doi.org/10.1016/j.phymed.2007.03.017] [PMID: 17482444]
[143]
Chauhan SP, Sheth NR, Jivani NP, Rathod IS, Shah PI. Biological actions of Opuntia species. Syst Rev Pharm 2011; 1(2): 146-51.
[http://dx.doi.org/10.4103/0975-8453.75064]
[144]
Serra AT, Poejo J, Matias AA, Bronze MR, Duarte CMM. Evaluation of Opuntia spp. derived products as antiproliferative agents in human colon cancer cell line (HT29). Food Res Int 2013; 54(1): 892-901.
[http://dx.doi.org/10.1016/j.foodres.2013.08.043]
[145]
Dahab RA, Afifi F. Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7). Sci Pharm 2007; 75: 121-36.
[http://dx.doi.org/10.3797/scipharm.2007.75.121]
[146]
Zou DM, Brewer M, Garcia F, et al. Cactus pear: a natural product in cancer chemoprevention. Nutr J 2005; 4(25): 25.
[http://dx.doi.org/10.1186/1475-2891-4-25] [PMID: 16150152]
[147]
Abdulazeem L, Alaq FTA, Alrubaei HA, Mawlah YHA, Alwan WK. Anti-Cancer Activity of Opuntia polyacantha alkaloid extract on human breast cancer cell line. J Pharm Sci Res 2018; 10(7): 1753-4.
[148]
Hahm SW, Park J, Park KY, Son YS, Han H. Extracts of Opuntia humifusa fruits inhibit the growth of AGS human gastric adenocarcinoma cells. Prev Nutr Food Sci 2016; 21(1): 31-7.
[http://dx.doi.org/10.3746/pnf.2016.21.1.31] [PMID: 27069903]
[149]
Keller J, Camaré C, Bernis C, et al. Antiatherogenic and antitumoral properties of Opuntia cladodes: inhibition of low density lipoprotein oxidation by vascular cells, and protection against the cytotoxicity of lipid oxidation product 4-hydroxynonenal in a colorectal cancer cellular model. J Physiol Biochem 2015; 71(3): 577-87.
[http://dx.doi.org/10.1007/s13105-015-0408-x] [PMID: 25840808]
[150]
Antunes-Ricardo M, Moreno-García BE, Gutiérrez-Uribe JA, Aráiz-Hernández D, Alvarez MM, Serna-Saldivar SO. Induction of apoptosis in colon cancer cells treated with isorhamnetin glycosides from Opuntia ficus-indica pads. Plant Foods Hum Nutr 2014; 69(4): 331-6.
[http://dx.doi.org/10.1007/s11130-014-0438-5] [PMID: 25186940]
[151]
Akacha A, Rebai T, Zourgui L, Amri M. Preventive effect of ethanolic extract of cactus (Opuntia ficus-indica) cladodes on methotrexate-induced oxidative damage of the small intestine in Wistar rats. J Cancer Res Ther 2018; 14(Suppl.): S779-84.
[http://dx.doi.org/10.4103/0973-1482.174555] [PMID: 30249903]
[152]
Chavez-Santoscoy RA, Gutierrez-Uribe JA, Serna-Saldívar SO, Saldivar SOS. Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices. Plant Foods Hum Nutr 2009; 64(2): 146-52.
[http://dx.doi.org/10.1007/s11130-009-0117-0] [PMID: 19468836]
[153]
Poejo J, Matias AA, Bronze MR, Duarte CMM, Serra AT. Evaluation of cactus pear (Opuntia spp.) extracts as promising bioactive ingredients for colon cancer therapy. Eur J Pharmacol 2011.66e18
[http://dx.doi.org/10.1016/j.ejphar.2011.09.235]
[154]
Kumar AS, Ganesh M, Peng MM, Jang HT. Phytochemical, anti-oxidant, antiviral and cytotoxic evaluation of Opuntia dillenii flowers. Bangladesh J Pharmacol 2014; 9: 351-5.
[http://dx.doi.org/10.3329/bjp.v9i3.19489]
[155]
Prabhakaran D, Senthamilselvi MM, Rajeshkanna A. Anticancer activity of Opuntia stricta (Flowers) against human liver cancer (HEPG2) cell line. J Pharm Res 2017; 11(7): 793-7.
[156]
Kaur M, Kaur A, Sharma R. Pharmacological actions of Opuntia ficus indica: a review. J Appl Pharm Sci 2012; 2(7): 15-8.
[http://dx.doi.org/10.7324/JAPS.2012.2703]
[157]
Ahmad A, Davies J, Randall S, Skinner GR. Antiviral properties of extract of Opuntia streptacantha. Antiviral Res 1996; 30(2-3): 75-85.
[http://dx.doi.org/10.1016/0166-3542(95)00839-X] [PMID: 8783800]
[158]
Rasoulpour R, Afsharifar A, Zadpanah K. Antiviral activity of prickly pear (Opuntia ficus-indica (L.) Miller) extract: Opuntin B, a second antiviral protein. Crop Prot 2018; 112: 1-9.
[http://dx.doi.org/10.1016/j.cropro.2018.04.017]
[159]
Shaukat TM, Ashraf M, Omer MO, et al. Comparative efficacy of various antiviral agents against avian influenza virus. Pak J Zool 2011; 43(5): 849-54.
[160]
Wiese J, McPherson S, Odden MC, Shlipak MG. Effect of Opuntia ficus indica on symptoms of the alcohol hangover. Arch Intern Med 2004; 164(12): 1334-40.
[http://dx.doi.org/10.1001/archinte.164.12.1334] [PMID: 15226168]
[161]
Hwang SH, Kang J, Lim SS. Antidiabetic Effect of fresh nopal (Opuntia ficus-indica) in low-dose streptozotocin-induced diabetic rats fed a high-fat diet. Evid Based Complement Alternat Med 2017; 20174380721
[http://dx.doi.org/10.1155/2016/8983232] [PMID: 28303158]
[162]
Lee YK, Lee HS, Kim BW. Effect of short-term feeding of dietary fiber supplements on glucose metabolism in subjects with non-insulin-dependent diabetes mellitus. J Korean Soc Food Sci Nutr 1996; 25: 846-54.
[163]
Frati AC, Jimiinez E, Ariza CR. Hypoglycemic Effect of Opuntia jicus indica in non insulin-dependent diabetes mellitus patients. Phytother Res 1990; 4(5): 195-7.
[http://dx.doi.org/10.1002/ptr.2650040507]
[164]
Frati-Munari AC, Del Valle-Martinez LM, Ariza-Andraca CR, Islas-Andrade S, Chavez-Negrete A. Hypoglycemic effect of different doses of nopal (Opuntia streptacantha Lemaire) in patients with type II diabetes mellitus. Arch Invest Med (Mex) 1989; 2: 97-201.
[165]
Frati AC, Gordillo BE, Altamirano P, et al. Influence of nopal intake upon fasting glycemia in type II diabetics and healthy subjects. Arch Invest Med (Mex) 1991; 22(1): 51-6.
[PMID: 1668138]
[166]
López-Romero P, Pichardo-Ontiveros E, Avila-Nava A, et al. The effect of nopal (Opuntia ficus indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. J Acad Nutr Diet 2014; 114(11): 1811-8.
[http://dx.doi.org/10.1016/j.jand.2014.06.352] [PMID: 25132122]
[167]
Ibarra-Salas MJ, Novelo-Huerta HI, De León-Salas MA, Sánchez-Murillo ME, Mata-Obregón MDC, Garza-Juárez AJ. Glycemic index and glycemic load in the Opuntia ficus-indica fruit. Gac Med Mex 2017; 153(4): 473-9.
[PMID: 28991272]
[168]
Jaya S, Kumar B. Hypoglycemic efficacy of Catharanthus roseus and Opuntia ficusindica in mice diabetic model. Int J Curr Microbiol Appl Sci 2017; 6(7): 1193-209.
[http://dx.doi.org/10.20546/ijcmas.2017.607.145]
[169]
González-Ponce HA, Martínez-Saldaña MC, Rincón-Sánchez AR, et al. Hepatoprotective effect of Opuntia robusta and Opuntia streptacantha fruits against acetaminophen-induced acute liver damage. Nutrients 2016; 8(10): 2-15.
[http://dx.doi.org/10.3390/nu8100607] [PMID: 27782042]
[170]
Chahdoura H, Adouni K, Khlifi A, et al. Hepatoprotective effect of Opuntia microdasys (Lehm.) Pfeiff flowers against diabetes type II induced in rats. Biomed Pharmacother 2017; 94: 79-87.
[http://dx.doi.org/10.1016/j.biopha.2017.07.093] [PMID: 28755576]
[171]
Djerrou Z, Maameri Z, Halmi H, et al. Hepatoprotective effect of Opuntia ficus-indica aqueous extract against carbon tetrachloride-induced toxicity in rats. Online J Biol Sci 2015; 15(2): 36-41.
[http://dx.doi.org/10.3844/ojbsci.2015.36.41]
[172]
Saleem M, Irshad I, Baig M, Naseer F. Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits. Bangladesh J Pharmacol 2015; 10: 16-20.
[http://dx.doi.org/10.3329/bjp.v10i1.20825]
[173]
Bouhrim M, Ouassou H, Choukri M, et al. Hepatoprotective effect of Opuntia dillenii seed oil on CCl4 induced acute liver damage in rat. Asian Pac J Trop Biomed 2018; 8(5): 254-60.
[http://dx.doi.org/10.4103/2221-1691.233006]
[174]
Kim JW, Kim TB, Kim HW, Park SW, Kim HP, Sung SH. Hepatoprotective flavonoids in Opuntia ficus-indica fruits by reducing oxidative stress in primary rat hepatocytes. Pharmacogn Mag 2017; 13(51): 472-6.
[http://dx.doi.org/10.4103/pm.pm_232_16] [PMID: 28839374]
[175]
Ben Saad A, Dalel B, Rjeibi I, et al. Phytochemical, antioxidant and protective effect of cactus cladodes extract against lithium-induced liver injury in rats. Pharm Biol 2017; 55(1): 516-25.
[http://dx.doi.org/10.1080/13880209.2016.1255976] [PMID: 27951739]
[176]
Shah A, Ahmad KR. Aziz1 N, Rahim S, Batool S, Suleman S, Abbas T, Kanwal MA. Hepatoprotective activity of Opuntia dillenii (ker gawl.) Haw. Fruit pulp extract against cadmium induced toxicity in mice. J Anim Plant Sci 2016; 26(5): 1471-8.
[177]
Zambonin L, Caliceti C, Vieceli Dalla Sega F, et al. Dietary phenolic acids act as effective antioxidants in membrane models and in cultured cells, exhibiting proapoptotic effects in leukaemia cells. Oxid Med Cell Longev 2012.2012839298
[http://dx.doi.org/10.1155/2012/839298] [PMID: 22792417]
[178]
Boutakiout A, Elothmani D, Hanine H, et al. Effects of different harvesting seasons on antioxidant activity and phenolic content of prickly pear cladode juice. J Saudi Soc Agric Sci 2018; 17: 471-80.
[http://dx.doi.org/10.1016/j.jssas.2016.11.005]
[179]
Esquivel OE, Moreno AOM, Alvarez VBA, Alvarez LDA, Giusti MM. Phenolics, betacyanins and antioxidant activity in Opuntia joconostle fruits. Food Res Int 2011; 44(7): 2160-8.
[http://dx.doi.org/10.1016/j.foodres.2011.02.011]
[180]
Toit AD, Wit MD, Osthoff G, Hugo A. Antioxidant properties of fresh and processed cactus pear cladodes from selected Opuntia ficus-indica and O. robusta cultivars. S Afr J Bot 2018; 118: 44-51.
[http://dx.doi.org/10.1016/j.sajb.2018.06.014]
[181]
Chahdoura H, Barreira JCM, Barros L, Buelga CS, Ferreira CFRF, Achour L. Seeds of Opuntia spp. as a novel high potential by-product: phytochemical characterization and antioxidant activity. Ind Crops Prod 2015; 65: 383-9.
[http://dx.doi.org/10.1016/j.indcrop.2014.11.011]
[182]
Wasnik DD, Tumane PM. In vitro antibacterial activity of Opuntia ficus-indica l. (prickly pear) against multiple drug resistant (MDR) bacteria isolated from clinical samples. World J Pharm Pharm Sci 2016; 5(3): 996-1006.
[183]
Gnanakalai K, Gopal R. In vitro antibacterial activities of Opuntia ficus indica stem and fruit extracts using disc diffusion method. International J Curr Pharma Rev Res 2016; 8(2): 68-9.
[184]
Sánchez E, Rivas Morales C, Castillo S, Leos-Rivas C, García-Becerra L, Ortiz Martínez DM. Antibacterial and antibiofilm activity of methanolic plant extracts against nosocomial microorganisms. Evid Based Complement Alternat Med 2016.20161572697
[http://dx.doi.org/10.1155/2016/1572697] [PMID: 27429633]
[185]
Salehi A, Kariminik A, Hasanabadi Z. Antibacterial activity of methanol extracts of 4 plants used in traditional herbal medicine of Kerman, Iran. Int Res J Appl Basic Sci 2013; 7(12): 911-4.
[186]
Ennouri M, Ammar I, Khemakhem B, Attia H. Chemical composition and antibacterial activity of Opuntia ficus-indica f. inermis (cactus pear) flowers. J Med Food 2014; 17(8): 908-14.
[http://dx.doi.org/10.1089/jmf.2013.0089] [PMID: 24650181]
[187]
Fox DI. Removing heavy metals in water: the interaction of cactus mucilage and arsenate (As (V)). USA: ACS Publications Paper 2012.
[188]
Braun RH, Cordero A, Ramacciotti J. Productividad ecologica y valor forrajero de tunales (Opuntia ficus-indica) de Los Llanos, Provincia de La Rioja. Cuaderno Tecnico IADIZA 1979; 1: 29-37.
[189]
Ricarte RA, Gomez JC, Reynoso AA. Diagnóstico de las plantaciones de tuna (Opuntia ficus-indica) en los departamentos Chamical y General Belgrano, La Rioja.In: Estudios sobre pastizales naturales y el cultivo de la tuna. La Rioja, Argentina: Instituto de Zonas Aridas 1998; pp. 59-101.
[190]
Ribeiro EMO, Silva NH, Filho JLL, Brito JZB, Silva MPC. Study of carbohydrates present in the cladodes of Opuntia ficus-indica (fodder palm), according to age and season. Cienc Tecnol Aliment Campinas 2010; 30(4): 933-9.
[http://dx.doi.org/10.1590/S0101-20612010000400015]
[191]
Lopez-Garcia JJ, Fuentes-Rodriguez JM, Rodriguez RA. Production and use of Opuntia as forage in Northern Mexico. In: In: Mondragon-Jacobo, Perez-Gonzalez, Eds Cactus (Opuntia spp) as Forage FAO Plant production and protection papers Rome: FAO. 2011; 169: p. 161.
[192]
Dornelas M, Barbosa AM. Palma, cadeia produtiva da alimentaçao. Recife: SENAR-AR/PE 2003; pp. 8-9.
[193]
Neffar S, Chenchouni H, Beddiar A, Redjel N. Rehabilitation of degraded rangeland in drylands by prickly pear (Opuntia ficus-indica L.) Plantations: effect on soil and spontaneous vegetation. Ecol Balk 2013; 5: 63-76.
[194]
Vasquez-Mendez R, Ventura-Ramos E, Oleschko K, Hernandez-Sandoval L, Parrot JF, Nearing MA. Soil erosion and runoff in different vegetation patches from semiarid Central Mexico. Catena 2010; 80: 162-9.
[http://dx.doi.org/10.1016/j.catena.2009.11.003]
[195]
Hassan S, Inglesea P, Gristina L, et al. Root growth and soil carbon turnover in Opuntia ficus-indica as affected by soil volume availability Eur J Agron 2019; 105: 104-10.
[http://dx.doi.org/10.1016/j.eja.2019.02.012]


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 16
ISSUE: 8
Year: 2020
Page: [1227 - 1244]
Pages: 18
DOI: 10.2174/1573401316666200220092414
Price: $65

Article Metrics

PDF: 36
HTML: 2
EPUB: 1
PRC: 1