Amino acids (AAs) and their metabolites regulate key metabolic pathways that are necessary
for growth, reproduction, immunity and metabolism of the body. It has been convinced that metabolic
diseases are closely related to disorders of glycolipid metabolism. A growing number of studies
have shown that AAs are closely related to energy metabolism. This review focuses on the effects of
amino acids (arginine, branched-chain amino acids, glutamine) and their metabolites (short chain fatty
acids) on glycolipid metabolism by regulating PI3K/AKT/mTOR and AMPK signaling pathways and
GPCRs receptors, reducing intestinal Firmicutes/Bacteroidetes ratio associated with obesity.
Keywords: Glycolipid metabolism, amino acids (AAs), short chain fatty acids (SCFAs), intestinal microbial composition,
metabolic pathways, metabolites.
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