Amino Acids Regulate Glycolipid Metabolism and Alter Intestinal Microbial Composition

Author(s): Fei Xie, Zhengqun Liu, Ming Liu, Liang Chen, Wei Ding*, Hongfu Zhang*

Journal Name: Current Protein & Peptide Science

Volume 21 , Issue 8 , 2020


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Abstract:

Amino acids (AAs) and their metabolites regulate key metabolic pathways that are necessary for growth, reproduction, immunity and metabolism of the body. It has been convinced that metabolic diseases are closely related to disorders of glycolipid metabolism. A growing number of studies have shown that AAs are closely related to energy metabolism. This review focuses on the effects of amino acids (arginine, branched-chain amino acids, glutamine) and their metabolites (short chain fatty acids) on glycolipid metabolism by regulating PI3K/AKT/mTOR and AMPK signaling pathways and GPCRs receptors, reducing intestinal Firmicutes/Bacteroidetes ratio associated with obesity.

Keywords: Glycolipid metabolism, amino acids (AAs), short chain fatty acids (SCFAs), intestinal microbial composition, metabolic pathways, metabolites.

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Article Details

VOLUME: 21
ISSUE: 8
Year: 2020
Published on: 09 November, 2020
Page: [761 - 765]
Pages: 5
DOI: 10.2174/1389203721666200219100216
Price: $65

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