Aim and Objective: Platinum (II) and platinum (IV) of pyrophosphate complexes have
been prepared and characterized to discover their potential as antitumor drugs. This study was
conducted to prepare and characterize new ternary platinum (II) complexes with formamidine and
pyrophosphate as an antitumor candidate.
Materials and Methods: The complexes have been characterized by mass, infrared, UV-Vis.
spectroscopy, elemental analysis, magnetic susceptibility, thermal analyses, and theoretical
calculations. They have been tested for their cytotoxicity, which was carried out using the fastcolorimetric
assay for cellular growth and survival against MCF-7 (breast cancer cell line), HCT-
116 (colon carcinoma cell line), and HepG-2 (hepatocellular cancer cell line).
Results: All complexes are diamagnetic, and the electronic spectral data displayed the bands due
to square planar Pt(II) complexes. The optimized complexes structures (1-4) indicated a distorted
square planar geometry where O-Pt-O and N-Pt-N bond angles were 82.04°-96.44°, respectively.
Results also show that all complexes are neutral, stable and non-hygroscopic and have noticeable
cytotoxicity with IC50 (μM): 0.035-0.144 MCF-7(breast cancer cell line), 0.042-0.187 HCT-116
(colon carcinoma cell line), and 0.063-0.168 HepG-2 (hepatocellular cancer cell line). Moreover,
the results show that the complex (4) has the best IC50 value.
Conclusion: The complexes showed noticeable cytotoxicity and are considered as promising
antitumor candidates for further applications.