Title:Phytochemical Composition, Pharmacological Properties, and Therapeutic Applications of Celastrus paniculatus
VOLUME: 7 ISSUE: 1
Author(s):Hemanth Kumar Kandikattu*, Narayanappa Amruta, Farhath Khanum, V.V.P.C. Narayana and Doddaga Srinivasulu
Affiliation:Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, Department of Neuroscience, Tulane University School of Medicine, New Orleans, LA 70112, Biochemistry and Nanosciences Discipline, Defence Food Research Laboratory, Mysore-570011, Karnataka, Department of Chemistry, Sri Venkateswara University, Tirupati - 517 502, Andhra Pradesh, Department of Chemistry, Sri Venkateswara University, Tirupati - 517 502, Andhra Pradesh
Keywords:Celastrus paniculatus, jyothismathi, neuroprotection, anticancer, antioxidant, pharmacological
properties.
Abstract:Humans experience different kinds of stress as a part of the day to day activity.
The manifestation of stress will aggravate based on the physical conditions of individuals
and due to their socio-economic situation of living. Herbal extracts have long been used in
the traditional systems of medicine for the treatment of various ailments because of their potent
antioxidant activity and lesser or no side-effects. Recently, there is a surge of interest
toward the search of natural substances with diverse pharmacological activities, that can
scavenge free radicals and protect cells from oxidative damage and apoptosis because of the
adverse effects associated with the use of conventional medicines. Celastrus paniculatus is
an endangered medicinal plant used for years in the traditional Ayurvedic system of medicine.
The review presents the diverse chemical constituents of C. paniculatus and their
pharmacological actions such as neuroprotective, memory-enhancing, anti-depressant, anxiolytic,
anti-aging, hypolipidemic, anticancerous, analgesic, anti-inflammatory, antioxidant,
anti-apoptotic, gastroprotective, anti-ulcerative properties at the cellular and molecular level
based on the pre-clinical and clinical reports available. In the present review, we gathered the
information from sources, such as Google Scholar, Science direct, PUBMED, and reviewed
with a special focus on the mode of action of C. paniculatus at molecular biology from the
data on animal and preclinical experiments to cure various ailments. These diverse medicinal
values of C. paniculatus demonstrate its value as traditional medicine as a cure for multiple
maladies.
