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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

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Mini-Review Article

Biological Activity of MelAnnurca Flesh Apple Biophenols

Author(s): Daniela C. Vuoso, Marina Porcelli, Giovanna Cacciapuoti and Stefania D’Angelo*

Volume 16, Issue 8, 2020

Page: [1149 - 1162] Pages: 14

DOI: 10.2174/1573401316666200217113808

Price: $65

Abstract

Background: The apple is among the most consumed fruits in the world and several studies suggest that apple polyphenols could play a role in preventing degenerative diseases. Recent studies have shown that polyphenols possess a high antioxidant and/or anti-proliferative power, therefore their food intake could play a decisive role in the prevention of various pathologies, in particular those associated with the production of free radicals. The Annurca apple (MelAnnurca), a variety from southern Italy, is called the "queen of apples" due to its remarkable organoleptic qualities: taste, flavor and aroma. The Annurca apple is a constituent component of the Mediterranean diet and its potential health benefit could be attributed to a large amount of bioactive components; in fact, this apple is characterized by an extremely high content of polyphenols.

Objective: The aim of this paper was to review the most recent literature regarding the health benefits of Annurca apples and their phytochemicals. In particular, this review highlighted the effects of the flesh of this fruit on different types of human cells.

Methods: A literature research was performed using the keywords “Annurca”, “apple”, “flesh”, “fruit”, “polyphenols”, “nutrition”, “nutraceuticals”, individually or all together, in Scopus, Web of Science and PubMed.

Results: The MelAnnurca apple has a higher content of bioactive compounds (polyphenols) than other apples, making it an ideal source of nutraceuticals. Both the cytotoxic activity and the antioxidant effect of the extracts of polyphenols obtained from its flesh have been highlighted.

Conclusion: These results give new insights for future implementation of the production chain of the Annurca apple in the area of Campania, Southern Italy. However, although evidence to support the health benefits of MelAnnurca apple polyphenols is rapidly accumulating, further human studies may be needed before the public is convinced and willing to incorporate the apple Annurca into their diet, accepting the idea that the integration of polyphenols has a beneficial effect on the health of the human body.

Keywords: Annurca, apple, antioxidant, flesh, nutraceuticals, nutrition, polyphenols, proliferation.

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[1]
Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 1992; 18(1): 1-29.
[http://dx.doi.org/10.1080/01635589209514201] [PMID: 1408943]
[2]
Malin AS, Qi D, Shu XO, et al. Intake of fruits, vegetables and selected micronutrients in relation to the risk of breast cancer. Int J Cancer 2003; 105(3): 413-8.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1780272/
[http://dx.doi.org/10.1002/ijc.11088] [PMID: 12704679]
[3]
Joshipura KJ, Hu FB, Manson JE, et al. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 2001; 134(12): 1106-14.
[http://dx.doi.org/10.7326/0003-4819-134-12-200106190-00010] [PMID: 11412050]
[4]
Knekt P, Kumpulainen J, Järvinen R, et al. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002; 76(3): 560-8.https://academic.oup.com/ajcn/article/76/3/560/4677422
[http://dx.doi.org/10.1093/ajcn/76.3.560] [PMID: 12198000]
[5]
Hollman PC, Katan MB. Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 1997; 51(8): 305-10.
[http://dx.doi.org/10.1016/S0753-3322(97)88045-6] [PMID: 9436520]
[6]
Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003; 78(3)(Suppl.): 517S-20S.https://academic.oup.com/ajcn/article/78/3/517S/4689990
[http://dx.doi.org/10.1093/ajcn/78.3.517S] [PMID: 12936943]
[7]
Koch TC, Briviba K, Watzl B, et al. Prevention of colon carcinogenesis by apple juice in vivo: impact of juice constituents and obesity. Mol Nutr Food Res 2009; 53(10): 1289-302.
[http://dx.doi.org/10.1002/mnfr.200800457] [PMID: 19753605]
[8]
Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90(17): 7915-22.
[http://dx.doi.org/10.1073/pnas.90.17.7915] [PMID: 8367443]
[9]
Boyer J, Liu RH. Apple phytochemicals and their health benefits. Nutr J 2004; 3: 5.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442131/
[http://dx.doi.org/10.1186/1475-2891-3-5] [PMID: 15140261]
[10]
Hyson DA. A comprehensive review of apples and apple components and their relationship to human health. Adv Nutr 2011; 2(5): 408-20.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183591/
[http://dx.doi.org/10.3945/an.111.000513] [PMID: 22332082]
[11]
Gerhauser C. Cancer chemopreventive potential of apples, apple juice, and apple components Planta Med 2008; 74(13): 1608-24.. https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0028-1088300
[http://dx.doi.org/10.1055/s-0028-1088300] [PMID: 18855307]
[12]
Vinson JA, Su X, Zubik L, Bose P. Phenol antioxidant quantity and quality in foods: fruits. J Agric Food Chem 2001; 49(11): 5315-21.
[http://dx.doi.org/10.1021/jf0009293] [PMID: 11714322]
[13]
Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993; 342(8878): 1007-11.
[http://dx.doi.org/10.1016/0140-6736(93)92876-U] [PMID: 8105262]
[14]
Knekt P, Järvinen R, Seppänen R, et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997; 146(3): 223-30.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a009257 PMID: 9247006]
[15]
Juniper BE, Mabberley DJ. The Story of the Apple. Portland, Oregon, U.S.A.: Timber Press, Inc. 2006; pp. 27204-3527.
[16]
Food and Agriculture Organization (FAO) [accessed on 15 July 2013] Available from:. http://faostat3.fao.org/home/index.html
[17]
Tu SH, Chen LC, Ho YS. An apple a day to prevent cancer formation: Reducing cancer risk with flavonoids. Yao Wu Shi Pin Fen Xi 2017; 25(1): 119-24.
[http://dx.doi.org/10.1016/j.jfda.2016.10.016] [PMID: 28911529]
[18]
Sun J, Chu YF, Wu X, Liu RH. Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem 2002; 50(25): 7449-54.
[http://dx.doi.org/10.1021/jf0207530] [PMID: 12452674]
[19]
Lintas C, Paoletti F, Cappelloni M, Gabelli L, Monastra F, Ponziani G. Agronomic, nutritional, and texture evaluation of “Annurca” apple clones. Adv Hortic Sci 1993; 7(4): 165-8.
[20]
Napolitano A, Cascone A, Graziani G, et al. Influence of variety and storage on the polyphenol composition of apple flesh. J Agric Food Chem 2004; 52(21): 6526-31.
[http://dx.doi.org/10.1021/jf049822w] [PMID: 15479018]
[21]
D’Angelo S, Cimmino A, Raimo M, Salvatore A, Zappia V, Galletti P. Effect of reddening-ripening on the antioxidant activity of polyphenol extracts from cv. ‘Annurca’ apple fruits. J Agric Food Chem 2007; 55(24): 9977-85.
[http://dx.doi.org/10.1021/jf071773a] [PMID: 17960886]
[22]
Application for approval of a minor amendment in accordance with the second subparagraph of Article 53(2) of Regulation (EU) No 1151/2012 (2) ‘MELANNURCA CAMPANA’. Information and Notices. Official J European Union C 174 2016; 59(14): 19-25. Abailable from: . https://eur-lex.europa.eu/legal-content/IT/TXT/? uri=OJ%3AC%3A2016%3A174%3AFULL
[23]
Carnovale E, Marletta L. Tabelle di Composizione degli Alimenti-Aggiornamento 2000 Inran - ed EDRA Available from:. 2000.http://www.clitt.it/contents/scienze-files/6160_rodato_quaderno-files/6160_TabelleComposAlim.pdf
[24]
Peng C, Wang X, Chen J, et al. Biology of ageing and role of dietary antioxidants. BioMed Res Int 2014; 2014831841https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996317/
[http://dx.doi.org/10.1155/2014/831841] [PMID: 24804252]
[25]
Berrino F, Muti P. Mediterranean diet and cancer. Eur J Clin Nutr 1989; 43(Suppl. 2): 49-55.
[PMID: 2557204]
[26]
Gallus S, Bosetti C, La Vecchia C. Mediterranean diet and cancer risk. Eur J Cancer Prev 2004; 13(5): 447-52.
[http://dx.doi.org/10.1097/00008469-200410000-00013 PMID: 15452458]
[27]
Mentella MC, Scaldaferri F, Ricci C, Gasbarrini A, Miggiano GAD. Cancer and mediterranean diet: a review. Nutrients 2019; 11(9)E2059
[http://dx.doi.org/10.3390/nu11092059] [PMID: 31480794]
[28]
Zappia V, Galletti P, Manna C, et al. Effects of hydroxytyrosol on cyclosporine nephrotoxicity Olives and olive oil in health and disease prevention. Oxford: Academic Press 2010; pp. 1245-52.
[http://dx.doi.org/10.1016/B978-0-12-374420-3.00136-4]
[29]
Gaforio JJ, Visioli F, Alarcón-de-la-Lastra C, et al. Virgin olive oil and health: summary of the iii international conference on virgin olive oil and health consensus report, JAEN (Spain) 2018. Nutrients 2019; 11(9)E2039https://www.ncbi.nlm.nih. gov/pmc/articles/PMC6770785/
[http://dx.doi.org/10.3390/nu11092039] [PMID: 31480506]
[30]
Motti ML. D Angelo S, Meccariello R. MicroRNAs, cancer and diet: facts and new exciting perspectives. Curr Mol Pharmacol 2018; 11(2): 90-6.
[http://dx.doi.org/10.2174/1874467210666171013123733 PMID: 29034844]
[31]
Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000; 130(8S Suppl): 2073S-85S..
[32]
D’Angelo S, Sammartino D. Protective effect of annurca apple extract against oxidative damage in human erythrocytes. Curr Nutr Food Sci 2015; 1(4): 248-56.
[http://dx.doi.org/10.2174/1573401311666150610210529]
[33]
Manna C, D’Angelo S, Migliardi V, et al. Protective effect of the phenolic fraction from virgin olive oils against oxidative stress in human cells. J Agric Food Chem 2002; 50(22): 6521-6.
[http://dx.doi.org/10.1021/jf020565+] [PMID: 12381144]
[34]
D’Angelo S, Ingrosso D, Migliardi V, et al. Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radic Biol Med 2005; 38(7): 908-19.
[http://dx.doi.org/10.1016/j.freeradbiomed.2004.12.015] [PMID: 15749387]
[35]
D’Angelo S, Manna C, Migliardi V, et al. Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil. Drug Metab Dispos 2001; 29(11): 1492-8.
[PMID: 11602527]
[36]
Del Monaco G, Officioso A, D’Angelo S, et al. Characterization of extra virgin olive oils produced with typical Italian varieties by their phenolic profile. Food Chem 2015; 184: 220-8.
[http://dx.doi.org/10.1016/j.foodchem.2015.03.071 PMID: 25872448]
[37]
Manna C, Della Ragione F, Cucciolla V, et al. Biological effects of hydroxytyrosol, a polyphenol from olive oil endowed with antioxidant activity. In: Zappia V, Della Ragione F, Barbarisi A, Russo GL, Iacovo RD, Eds. Advances in Nutrition and Cancer 2 Advances in Experimental Medicine and Biology. Boston, MA: Springer 1999; 472: pp. 115-30..
[38]
Wolfe K, Xianzhong W, Hai LR, et al. Antioxidant activity of apple peels. J Agric Food Chem 2003; 51(3): 609-14.
[PMID: 12537430]
[39]
Eberhardt MV, Lee CY, Liu RH. Antioxidant activity of fresh apples. Nature 2000; 405(6789): 903-4.
[http://dx.doi.org/10.1038/35016151] [PMID: 10879522]
[40]
Shahidi F, Ed. Handbook of antioxidants for food preservation. UK: Woodhead Publishing/Elsevier 2015.
[41]
Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients 2010; 2(12): 1231-46.
[http://dx.doi.org/10.3390/nu2121231] [PMID: 22254006]
[42]
Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998; 56(11): 317-33.https://academic.oup.com/nutritionreviews/article/56/11/317/1901722
[43]
Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2009; 2(5): 270-8.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/
[http://dx.doi.org/10.4161/oxim.2.5.9498] [PMID: 20716914]
[44]
Tapas AR, Sakarkar DM, Kakde RB. Flavonoids as nutraceuticals: a review. Trop J Pharm Res 2008; 7(3): 1089-99.
[http://dx.doi.org/10.4314/tjpr.v7i3.14693]
[45]
Lall RK, Syed DN, Adhami VM, Khan MI, Mukhtar H. Dietary polyphenols in prevention and treatment of prostate cancer. Int J Mol Sci 2015; 16(2): 3350-76.
[http://dx.doi.org/10.3390/ijms16023350] [PMID: 25654230]
[46]
D’Angelo S, Martino E, Cacciapuoti G. Effects of Annurca Apple (Malus pumila cv Annurca) Polyphenols on Breast Cancer Cells. Curr Nutr Food Sci 2019; 15(7): 745-51.
[http://dx.doi.org/10.2174/1573401315666190206142025]
[47]
Durazzo A, Lucarini M, Souto EB, et al. Polyphenols: A concise overview on the chemistry, occurrence, and human health. Phytother Res 2019; 33(9): 2221-43.
[http://dx.doi.org/10.1002/ptr.6419] [PMID: 31359516]
[48]
Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004; 79(5): 727-47.
[http://dx.doi.org/10.1093/ajcn/79.5.727] [PMID: 15113710]
[49]
Pérez-Jiménez J, Neveu V, Vos F, Scalbert A. Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. Eur J Clin Nutr 2010; 64(Suppl. 3): S112-20.
[http://dx.doi.org/10.1038/ejcn.2010.221] [PMID: 21045839]
[50]
Cheynier V. Polyphenols in foods are more complex than often thought. Am J Clin Nutr 2005; 81(1)(Suppl.): 223S-9S.
[http://dx.doi.org/10.1093/ajcn/81.1.223S] [PMID: 15640485]
[51]
Quideau S, Deffieux D, Douat-Casassus C, Pouységu L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl 2011; 50(3): 586-621.
[http://dx.doi.org/10.1002/anie.201000044] [PMID: 21226137]
[52]
Kennedy DO, Wightman EL. Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function. Adv Nutr 2011; 2(1): 32-50.
[http://dx.doi.org/10.3945/an.110.000117]] [PMID: 22211188]
[53]
Crozier A, Jaganath IB, Clifford MN. Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 2009; 26(8): 1001-43.
[http://dx.doi.org/10.1039/b802662a] [PMID: 19636448]
[54]
D’Angelo S, Morana A, Salvatore A, Zappia V, Galletti P. Protective effect of polyphenols from Glycyrrhiza glabra against oxidative stress in Caco-2 cells. J Med Food 2009; 12(6): 1326-33.
[http://dx.doi.org/10.1089/jmf.2008.0285] [PMID: 20041789]
[55]
Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr 2005; 81(1)(Suppl.): 215S-7S.
[http://dx.doi.org/10.1093/ajcn/81.1.215S] [PMID: 15640483]
[56]
Padayachee A, Netzel G, Netzel M, et al. Binding of polyphenols to plant cell wall analogues-Part 1. Anthocyanins Food Chem 2012; 134(1): 155-61.
[http://dx.doi.org/10.1016/j.foodchem.2012.02.082]
[57]
Padayachee A, Netzel G, Netzel M, et al. Binding of polyphenols to plant cell wall analogues - Part 2: Phenolic acids. Food Chem 2012; 135(4): 2287-92.
[http://dx.doi.org/10.1016/j.foodchem.2012.07.004 PMID: 22980803]
[58]
Alonso-Salces RM, Ndjoko K, Queiroz EF, et al. On-line characterisation of apple polyphenols by liquid chromatography coupled with mass spectrometry and ultraviolet absorbance detection. J Chromatogr A 2004; 1046(1-2): 89-100.
[http://dx.doi.org/10.1016/j.chroma.2004.06.077] [PMID: 15387175]
[59]
Lotito SB, Actis-Goretta L, Renart ML, et al. Influence of oligomer chain length on the antioxidant activity of procyanidins. Biochem Biophys Res Commun 2000; 276(3): 945-51.
[http://dx.doi.org/10.1006/bbrc.2000.3571] [PMID: 11027573]
[60]
Neveu V, Perez-Jiménez J, Vos F, et al. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods Database (Oxford) 2010; 2010bap024..
[http://dx.doi.org/10.1093/database/bap024] [PMID: 20428313]
[61]
Fu L, Xu BT, Xu XR, et al. Antioxidant capacities and total phenolic contents of 62 fruits. Food Chem 2011; 129(2): 345-50.
[http://dx.doi.org/10.1016/j.foodchem.2011.04.079 PMID: 30634236]
[62]
Kalinowska M, Bielawska A, Lewandowska-Siwkiewicz H, Priebe W, Lewandowski W. Apples: content of phenolic compounds vs. variety, part of apple and cultivation model, extraction of phenolic compounds, biological properties. Plant Physiol Biochem 2014; 84: 169-88.
[http://dx.doi.org/10.1016/j.plaphy.2014.09.006] [PMID: 25282014]
[63]
Wojdyło A, Oszmiański J, Laskowski P. Polyphenolic compounds and antioxidant activity of new and old apple varieties. J Agric Food Chem 2008; 56(15): 6520-30.
[http://dx.doi.org/10.1021/jf800510j] [PMID: 18611028]
[64]
Lamperi L, Chiuminatto U, Cincinelli A, et al. Polyphenol levels and free radical scavenging activities of four apple cultivars from integrated and organic farming in different italian areas. J Agric Food Chem 2008; 56(15): 6536-46.
[http://dx.doi.org/10.1021/jf801378m] [PMID: 18642842]
[65]
Tsao R, Yang R, Young JC, Zhu H. Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). J Agric Food Chem 2003; 51(21): 6347-53.
[http://dx.doi.org/10.1021/jf0346298] [PMID: 14518966]
[66]
Tenore GC, Campiglia P, Stiuso P, Ritieni A, Novellino E. Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca). Food Chem 2013; 140(4): 614-22.
[http://dx.doi.org/10.1016/j.foodchem.2012.10.112] [PMID: 23692744]
[67]
Fratianni F, Sada A, Cipriano L, Masucci A, Nazzaro F. Biochemical characteristics, antimicrobial and mutagenic activity in organically and conventionally produced Malus domestica, Annurca. Open Food Sci J 2007; 1: 10-6.
[http://dx.doi.org/10.2174/1874256400701010010]
[68]
Francini A, Sebastiani L. Phenolic compounds in Apple (Malus x domestica Borkh.): compounds characterization and stability during postharvest and after processing. Antioxidants 2013; 2(3): 181-93.
[http://dx.doi.org/10.3390/antiox2030181] [PMID: 26784345]
[69]
Graziani G, D’Argenio G, Tuccillo C, et al. Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo. Gut 2005; 54(2): 193-200.
[http://dx.doi.org/10.1136/gut.2004.046292] [PMID: 15647180]
[70]
Scafuri B, Marabotti A, Carbone V, Minasi P, Dotolo S, Facchiano A. A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer. Sci Rep 2016; 6(6): 32516.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009435/
[http://dx.doi.org/10.1038/srep32516] [PMID: 27587238]
[71]
Ehrenkranz JRL, Lewis NG, Kahn CR, Roth J. Phlorizin: a review. Diabetes Metab Res Rev 2005; 21(1): 31-8.
[http://dx.doi.org/10.1002/dmrr.532] [PMID: 15624123]
[72]
Leifert WR, Abeywardena MY. Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutr Res 2008; 28(12): 842-50.
[http://dx.doi.org/10.1016/j.nutres.2008.09.001] [PMID: 19083497]
[73]
Sommella E, Badolati N, Riccio G, et al. A Boost in mitochondrial activity underpins the cholesterol-lowering effect of Annurca apple polyphenols on hepatic cells. Nutrients 2019; 11(1)E163
[http://dx.doi.org/10.3390/nu11010163] [PMID: 30646510]
[74]
Tenore GC, Campiglia P, Ritieni A, Novellino E. In vitro bioaccessibility, bioavailability and plasma protein interaction of polyphenols from Annurca apple (M. pumila Miller cv Annurca). Food Chem 2013; 141(4): 3519-24.
[http://dx.doi.org/10.1016/j.foodchem.2013.06.051 PMID: 23993515]
[75]
D’Archivio M, Filesi C, Di Benedetto R, Gargiulo R, Giovannini C, Masella R. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita 2007; 43(4): 348-61.
[http://dx.doi.org/old.iss.it/publ/anna/2007/4/434348.pdf PMID: 18209268]
[76]
Tenore GC, Caruso D, Buonomo G, et al. Annurca (Malus pumila Miller cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: results of a randomized clinical trial. J Sci Food Agric 2017; 97(7): 2107-15.
[http://dx.doi.org/10.1002/jsfa.8016] [PMID: 27571713]
[77]
Tenore GC, Caruso D, Buonomo G, et al. Lactofermented Annurca apple puree as a functional food indicated for the control of plasma lipid and oxidative amine levels: results from a randomised clinical trial. Nutrients 2019; 11(1)E122
[http://dx.doi.org/10.3390/nu11010122] [PMID: 30634393]
[78]
Tenore GC, Calabrese G, Stiuso P, Ritieni A, Giannetti D, Novellino E. Effects of Annurca apple polyphenols on lipidmetabolism in HepG2 cell lines: a source of nutraceuticals potentially indicated for the metabolic syndrome. J Sci Food Agric 2014; 97(7): 2107-15.
[79]
Badolati N, Sommella E, Riccio G, et al. Annurca apple polyphenols ignite keratin production in hair follicles by inhibiting the pentose phosphate pathway and amino acid oxidation. Nutrients 2018; 10(10)E1046
[http://dx.doi.org/10.3390/nu10101406] [PMID: 30279339]
[80]
Tenore GC, Caruso D, Buonomo G, et al. Annurca apple nutraceutical formulation enhances keratin expression in a human model of skin and promotes hair growth and tropism in a randomized clinical trial. J Med Food 2018; 21(1): 90-103.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775114/
[http://dx.doi.org/10.1089/jmf.2017.0016] [PMID: 28956697]
[81]
Riccio G, Sommella E, Badolati N, et al. Annurca apple polyphenols protect murine hair follicles from taxane induced dystrophy and hijacks polyunsaturated fatty acid metabolism toward β-oxidation. Nutrients 2018; 10(11)E1808
[http://dx.doi.org/10.3390/nu10111808] [PMID: 30463345]
[82]
Kulbat K. The role of phenolic compounds in plant resistance. Biotechnol Food Sci 2016; 80: 97-108.
[83]
Vestergaard M, Ingmer H. Antibacterial and antifungal properties of resveratrol. Int J Antimicrob Agents 2019; 53(6): 716-23.
[http://dx.doi.org/10.1016/j.ijantimicag.2019.02.015 PMID: 30825504]
[84]
Jurikova T, Skrovankova S, Mlcek J, Balla S, Snopek L. Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos). Molecules 2018; 24(1)E24
[http://dx.doi.org/10.3390/molecules24010024] [PMID: 30577610]
[85]
Elansary HO, Szopa A, Kubica P, et al. Polyphenol Profile and Pharmaceutical Potential of Quercus spp Bark Extracts Plants (Basel) 2019; 8(11): pii: E486..
[86]
Fratianni F, Coppola R, Nazzaro F. Phenolic composition and antimicrobial and antiquorum sensing activity of an ethanolic extract of peels from the apple cultivar Annurca. J Med Food 2011; 14(9): 957-63.
[http://dx.doi.org/10.1089/jmf.2010.0170] [PMID: 21476926]
[87]
Fratianni F, De Giulio A, Sada A, Nazzaro F. Biochemical characteristics and biological properties of Annurca apple cider. J Med Food 2012; 15(1): 18-23.
[http://dx.doi.org/10.1089/jmf.2011.0042] [PMID: 21861727]
[88]
Stirpe M, Palermo V, Bianchi MM, et al. Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells. BMC Complement Altern Med 2017; 17(1): 200.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381082/
[http://dx.doi.org/10.1186/s12906-017-1666-7] [PMID: 28381226]
[89]
Xiang L, Sun K, Lu J, et al. Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes. Biosci Biotechnol Biochem 2011; 75(5): 854-8.
[http://dx.doi.org/10.1271/bbb.100774] [PMID: 21597195]
[90]
Tenore GC, D’Avino M, Caruso D, et al. Effect of Annurca apple polyphenols on intermittent claudication in patients with peripheral artery disease. Am J Cardiol 2019; 123(5): 847-53.
[http://dx.doi.org/10.1016/j.amjcard.2018.11.034] [PMID: 30573159]
[91]
Tenore GC, Caruso D, Buonomo G, et al. A Healthy balance of plasma cholesterol by a novel Annurca apple-based nutraceutical formulation: results of a randomized trial. J Med Food 2017; 20(3): 288-300.
[http://dx.doi.org/10.1089/jmf.2016.0152] [PMID: 28296588]
[92]
Sommella E, Ismail OH, Pagano F, et al. Development of an improved online comprehensive hydrophilic interaction chromatography × reversed-phase ultra-high-pressure liquid chromatography platform for complex multiclass polyphenolic sample analysis. J Sep Sci 2017; 40(10): 2188-97.
[http://dx.doi.org/10.1002/jssc.201700134] [PMID: 28349602]
[93]
Sommella E, Pepe G, Pagano F, et al. Detailed polyphenolic profiling of Annurca apple (M. pumila Miller cv Annurca) by a combination of RP-UHPLC and HILIC, both hyphenated to IT-TOF mass spectrometry. Food Res Int 2015; 76(Pt 3): 466-77.
[http://dx.doi.org/10.1016/j.foodres.2015.05.044] [PMID: 28455027]
[94]
Riccio G, Maisto M, Bottone S, et al. WNT inhibitory activity of Malus pumila miller cv Annurca and Malus domestica cv limoncella apple extracts on human colon-rectal cells carrying familial adenomatous polyposis mutations. Nutrients 2017; 9(11)E1262
[http://dx.doi.org/10.3390/nu9111262] [PMID: 29156563]
[95]
Fini L, Selgrad M, Fogliano V, et al. Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells. J Nutr 2007; 137(12): 2622-8.
[http://dx.doi.org/10.1093/jn/137.12.2622] [PMID: 18029474]
[96]
D’Angelo S, La Porta R, Napolitano M, Galletti P, Quagliuolo L, Boccellino M. Effect of Annurca apple polyphenols on human HaCaT keratinocytes proliferation. J Med Food 2012; 15(11): 1024-31.
[http://dx.doi.org/10.1089/jmf.2012.0076] [PMID: 22892038]
[97]
D’Angelo S, Martino E, Ilisso CP, Bagarolo ML, Porcelli M, Cacciapuoti G. Pro-oxidant and pro-apoptotic activity of polyphenol extract from Annurca apple and its underlying mechanisms in human breast cancer cells. Int J Oncol 2017; 51(3): 939-48.
[http://dx.doi.org/10.3892/ijo.2017.4088] [PMID: 28766690]
[98]
Martino E, Vuoso DC, D’Angelo S, et al. Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition. Sci Rep 2019; 9(1): 13045.
[http://dx.doi.org/10.1038/s41598-019-49631-x] [PMID: 31506575]

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