Atherosclerosis is a cardiovascular disease that involves vessels through the development of fatty
streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis by affecting various factors
that are involved in the disease. The present review discusses our current knowledge of the major cellular and
molecular mechanisms of phytotherapeutics for the treatment of atherosclerosis. Numerous studies have evaluated
the antiatherosclerotic activity of phytoconstituents to provide preliminary evidence of efficacy, but only a
few studies have delineated the underlying molecular mechanisms. Plant-derived phytotherapeutics primarily
targets abnormal levels of lipoproteins, endothelial dysfunction, smooth muscle cell migration, foam cell development,
and atheromatous plaque formation. Nonetheless, the principal mechanisms that are responsible for their
therapeutic actions remain unclear. Further pharmacological studies are needed to elucidate the underlying molecular
mechanisms of the antiatherosclerotic response to these phytoconstituents.
Keywords: Phytoconstituents, antiatherosclerotic, endothelial dysfunction, plaque formation, phytotherapeutics, atheromatous.
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