Ameliorative Effects and Cellular Aspects of Phytoconstituents in Atherosclerosis

Author(s): Alamgeer, Hira Asif, Muhammad Z.A. Sandhu, Madiha Aziz, Hafiz M. Irfan, Karyne G.T. Moreno, Arquimedes Gasparotto Junior*

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 22 , 2020

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Abstract:

Atherosclerosis is a cardiovascular disease that involves vessels through the development of fatty streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis by affecting various factors that are involved in the disease. The present review discusses our current knowledge of the major cellular and molecular mechanisms of phytotherapeutics for the treatment of atherosclerosis. Numerous studies have evaluated the antiatherosclerotic activity of phytoconstituents to provide preliminary evidence of efficacy, but only a few studies have delineated the underlying molecular mechanisms. Plant-derived phytotherapeutics primarily targets abnormal levels of lipoproteins, endothelial dysfunction, smooth muscle cell migration, foam cell development, and atheromatous plaque formation. Nonetheless, the principal mechanisms that are responsible for their therapeutic actions remain unclear. Further pharmacological studies are needed to elucidate the underlying molecular mechanisms of the antiatherosclerotic response to these phytoconstituents.

Keywords: Phytoconstituents, antiatherosclerotic, endothelial dysfunction, plaque formation, phytotherapeutics, atheromatous.

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Article Details

VOLUME: 26
ISSUE: 22
Year: 2020
Page: [2574 - 2582]
Pages: 9
DOI: 10.2174/1381612826666200214161139
Price: $65

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