Pathogenic Mechanisms and Therapeutic Implication in Nickel-Induced Cell Damage

Author(s): Ahmad Salimi*, Zhaleh Jamali, Saman Atashbar, Saleh Khezri, Amir M. Ghorbanpour, Nahid Etefaghi

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 20 , Issue 7 , 2020

Become EABM
Become Reviewer

Graphical Abstract:


Background: Nickel (Ni) is mostly applied in a number of industrial areas such as printing inks, welding, alloys, electronics and electrical professions. Occupational or environmental exposure to nickel may lead to cancer, allergy reaction, nephrotoxicity, hepatotoxicity, neurotoxicity, as well as cell damage, apoptosis and oxidative stress.

Methods: In here, we focused on published studies about cell death, carcinogenicity, allergy reactions and neurotoxicity, and promising agents for the prevention and treatment of the toxicity by Ni.

Results: Our review showed that in the last few years, more researches have focused on reactive oxygen species formation, oxidative stress, DNA damages, apoptosis, interaction with involving receptors in allergy and mitochondrial damages in neuron induced by Ni.

Conclusion: The collected data in this paper provide useful information about the main toxicities induced by Ni, also, their fundamental mechanisms, and how to discover new ameliorative agents for prevention and treatment by reviewing agents with protective and therapeutic consequences on Ni induced toxicity.

Keywords: Nickel, cell death, carcinogenicity, allergy reactions, neurotoxicity, mechanisms.

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Year: 2020
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DOI: 10.2174/1871530320666200214123118
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