Aim: The aim of this study was to evaluate the efficacy of honey-based ophthalmic drop
in patients with foreign body induced corneal ulcer.
Background: Honey is traditionally used for skin, mucosal and corneal ulcers. Its use is well studied
in human skin and mucosal ulcers and animal model of corneal ulcer with promising effects.
Methods: In this randomized clinical trial, 50 patients with foreign body induced corneal ulcer
were allocated to receive 70% sterile honey-based ophthalmic formulation or 0.3% ophthalmic
ciprofloxacin, as the standard treatment every 6 hours. All the patients were examined for the size
of corneal epithelial defect, corneal infiltration and depth and followed on a daily basis until complete
healing. Duration for complete healing was considered as the outcome measure. Smear, culture,
antibiogram and minimum inhibition concentration (MIC) tests were performed for honey
and ciprofloxacin in all patients.
Results: The average durations of complete healing of corneal epithelial defect in the honey and
ciprofloxacin groups were 3.88 ± 3.44 vs. 6.32 ± 3.69days, respectively (p=0.020). No significant
difference was observed between two groups regarding an average duration of healing of corneal
infiltration (8.12 ±1.94 days vs. 8.64±2.15 days, p=0.375). MIC of honey for pseudomonas aeruginosa
was 60%w/w, for E.Coli 40% w/w, and for staphylococcus aureus 30% w/w.
Conclusion: Honey based ophthalmic drop can acceleratethe corneal epithelial defect healing in
patients with foreign body induced corneal ulcer, compared to ophthalmic ciprofloxacin as a
The study was registered in Iranian registry of clinical trial center (IRCT) with registration number