Background: In the pharmaceutical field, it is vital to ensure a consistent product containing a single
solid-state form of the active pharmaceutical ingredient (API) in the drug product. However, some APIs are suffering
from the risk of transformation of their target forms during processing, formulation and storage.
Methods: The purpose of this review is to summarize the relevant category of excipients and demonstrate the
availability and importance of using excipients as a key strategy to manipulate pharmaceutical polymorphic transformation.
Results: The excipient effects on solvent-mediated phase transformations, solid-state transitions and amorphous
crystallization are significant. Common pharmaceutical excipients including amino acids and derivatives, surfactants,
and various polymers and their different manipulation effects were summarized and discussed.
Conclusion: Appropriate use of excipients plays a role in manipulating polymorphic transformation process of
corresponding APIs, with a promising application of guaranteeing the stability and effectiveness of drug dosage