Lignans from Medicinal Plants and their Anticancer Effect

Author(s): Eugenia Dumitra Teodor*, Veronica Moroeanu, Gabriel Lucian Radu

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 12 , 2020


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Abstract:

Since early times, various plants have been used as remedies for treating different kinds of diseases and lesions with satisfying results. The phenolic compounds are secondary metabolites from medicinal plants which include a wide category of compounds such as phenolic acids, flavonoids, tannins, stilbenes, curcuminoids, xanthones, coumarins, lignans, etc. Between these, lignans are considered important in cancer prevention and treatment, besides other beneficial health effects, e.g. antioxidant, anticarcinogenic, antimutagenic, and anti-estrogenic effects. This review summarizes the most recent literature and the most important results concerning plant lignans and their derivatives in cancer prevention and treatment, both in vitro and in vivo assessments. The mechanistic aspects will be also highlighted.

Keywords: Medicinal plants, lignans, cytotoxicity, anticancer effect, bioavailability, mechanism of action.

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Article Details

VOLUME: 20
ISSUE: 12
Year: 2020
Published on: 23 July, 2020
Page: [1083 - 1090]
Pages: 8
DOI: 10.2174/1389557520666200212110513
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