Background: Organoselenides are important building blocks of several biologically important
molecules and natural products. Several protocols have been developed by chemists for their synthesis.
Transition metal-catalyzed cross-coupling is a powerful tool for this purpose in the last two decades. Various
transition metal catalysts e.g. Pd, Ni, Cu, In etc. have been used for performing C-Se cross-coupling
in the presence or absence of ligands.
Objective: Development of a sustainable protocol for transition metal-catalyzed C-Se cross-coupling is
the main objective of this research. Recently, Cobalt has been applied as a cheap and sustainable transition
metal catalyst in several organic reactions. This protocol is focused on applying cobalt salt as a catalyst
for performing C-Se cross-coupling for the first time.
Methods: Co(acac)2 has been successfully employed for performing Se-arylations in the presence of CuI,
which acts as a co-catalyst under microwave irradiation. NMP was used as solvent and KOH as a reductant
in this reaction.
Results: Both iodo-and bromoarenes have been used to perform C-Se cross-coupling with diaryl
diselenide under this Co/Cu dual catalytic system. The reaction was successful with both electrondonating
and withdrawing groups in ortho-, meta-, and para-positions in the aromatic ring of Bromo and
Conclusion: This is an effective protocol for the preparation of organoselenides, catalyzed by cobalt in
the presence of copper. The mechanism has been established by several experimental techniques.