Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that has become a worldwide
health problem. This pathology has been classically characterized for its affectation on cognitive function and the
presence of depositions of extracellular amyloid β-protein (Aβ) and intracellular neurofibrillary tangles (NFT)
composed of hyperphosphorylated Tau protein. To this day, no effective treatment has been developed.
Multiple strategies have been proposed over the years with the aim of finding new therapeutic approaches, such
as the sequestration of Aβ in plasma or the administration of anti-inflammatory drugs. Also, given the significant
role of the insulin receptor in the brain in the proper maintenance of cognitive function, drugs focused on the
amelioration of insulin resistance have been proposed as potentially useful and effective in the treatment of AD.
In the present review, taking into account the molecular complexity of the disease, it has been proposed that the
most appropriate therapeutic strategy is a combinatory treatment of several drugs that will regulate a wide spectrum
of the described altered pathological pathways.