Lifestyle Modification with Physical Activity Promotion on Leptin Resistance and Quality of Life in Metabolic Syndrome - A Systematic Review with Meta-Analysis

Author(s): Anche Parameshwar, G. Arun Maiya*, Shobha Ullas Kamath, B. Ananthakrishna Shastry, Ravishankar

Journal Name: Current Diabetes Reviews

Volume 17 , Issue 3 , 2021

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Objective: This study focused to systematically extract, summarize and analyse the data on the effect of lifestyle modification on leptin resistance and quality of life in metabolic syndrome.

Methods: The systematic search was done using PubMed, Cochrane Database, EMBASE, Science Direct, CINAHL, Springer link, Web of Science from 2000-2018. English language articles and quantitative studies focusing on leptin resistance and quality of life were included. Random effect analysis was adopted to pool data and estimate 95% CI. The meta-analysis was done separately for leptin resistance and quality of life which included a total of 9 studies on both RCTs and Non-RCTs.

Results: The meta-analysis of RCTs reported insignificant effect of lifestyle modification on leptin resistance in metabolic syndrome when compared to comparison group (-5.94(-14.28, 2.41). Two clinical trials showed a significant effect with pooled data (5.52(2.14, 8.91). Meta-analysis of RCTs focusing on quality of life showed significant effect on mental component (4.89 (0.16, 9.62) of quality of life (2.36 (-3.67, 8.39) when compared to comparison group.

Conclusion: This meta-analysis suggested that lifestyle modification has a potential to improve leptin resistance and mental component of quality of life in metabolic syndrome. However, more clearly defined studies are required to come to a stronger conclusion.

Keywords: Metabolic syndrome, lifestyle modification, physical activity promotion, leptin resistance, quality of life, metaanalysis.

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Article Details

Year: 2021
Published on: 10 February, 2020
Page: [345 - 355]
Pages: 11
DOI: 10.2174/1573399816666200211102917
Price: $65

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