The Impact of Sarcopenic Obesity on Health-Related Quality of Life of Treatment-Seeking Patients with Obesity

Author(s): Leila Itani, Dima Kreidieh, Dana El Masri, Hana Tannir, Marwan El Ghoch*

Journal Name: Current Diabetes Reviews

Volume 16 , Issue 6 , 2020


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Abstract:

Background: There is a paucity of studies on health-related quality of life (HRQoL) and sarcopenic obesity (SO).

Objective: This study aimed to assess the potential association between SO and impaired HRQoL.

Methods: The ORWELL 97 questionnaire was used to assess HRQoL and body composition was measured using a bioimpedance analyser (Tanita BC-418) in 130 patients with obesity, referred to the Nutritional and Weight Management outpatient clinic of Beirut Arab University in Lebanon. Participants were then categorized on the basis of the absence or presence of SO.

Results: Sixty-four of the 130 participants met the criteria for SO (49.2%) and displayed significantly higher total ORWELL 97 scores than those in the group without SO (64.00 vs. 41.00, p=0.001), indicative of poorer HRQoL. Linear regression analysis showed that SO was associated with an increase in ORWELL 97 scores by nearly 24 units (β=24.35, 95% CI=11.45-37.26; p<0.0001). Moreover, the logistic regression analysis showed that SO increased the odds of clinically significant impairment of HRQoL (ORWELL 97 score ≥74.25) by nearly seven-fold (OR=7.37, 95% CI=1.92-28.39; p=0.004).

Conclusion: Our findings show that the presence of SO was associated with increased impairment of HRQoL that reaches clinical significance when compared to obesity only. Future studies are needed to clarify whether this may influence clinical outcomes. If this is shown to be the case, weight management programs should incorporate additional strategies to improve HRQoL in individuals with SO.

Keywords: BMI, obesity, sarcopenic obesity, quality of life, ORWELL 97, body composition.

[1]
Malafarina V, Uriz-Otano F, Iniesta R, Gil-Guerrero L. Sarcopenia in the elderly: diagnosis, physiopathology and treatment. Maturitas 2012; 71(2): 109-14.
[http://dx.doi.org/10.1016/j.maturitas.2011.11.012] [PMID: 22153348]
[2]
Kreidieh D, Itani L, El Kassas G, et al. Long-term lifestyle-modification programs for overweight and obesity management in the arab states: systematic review and meta-analysis. Curr Diabetes Rev 2018; 14(6): 550-8.
[http://dx.doi.org/10.2174/1573399813666170619085756] [PMID: 28625131]
[3]
Baalbaki R, Itani L, El Kebbi L, et al. Association between smoking hookahs (shishas) and higher risk of obesity: a systematic review of population-based studies. J Cardiovasc Dev Dis 2019; 6(2): 6.
[http://dx.doi.org/10.3390/jcdd6020023] [PMID: 31208138]
[4]
Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V. Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis 2008; 18(5): 388-95.
[http://dx.doi.org/10.1016/j.numecd.2007.10.002] [PMID: 18395429]
[5]
Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol 2018; 14(9): 513-37.
[http://dx.doi.org/10.1038/s41574-018-0062-9] [PMID: 30065268]
[6]
Tannir H, Kreidieh D, Itani L, El Masri D, El Ghoch M. Reduction of resting energy expenditure and sarcopenic obesity in adults with overweight and obesity: a brief report. Curr Diabetes Rev 2019; •••
[http://dx.doi.org/10.2174/1573399815666191030092138] [PMID: 31663844]
[7]
Nezameddin R, Itani L, Kreidieh D, El Masri D, Tannir H, El Ghoch M. Understanding sarcopenic obesity in terms of definition and health consequences: a clinical review. Curr Diabetes Rev 2020; •••
[http://dx.doi.org/10.2174/1573399816666200109091449] [PMID: 31916519]
[8]
Kreidieh D, Itani L, El Masri D, Tannir H, Citarella R, El Ghoch M. Association between sarcopenic obesity, type 2 diabetes, and hypertension in overweight and obese treatment-seeking adult women. J Cardiovasc Dev Dis 2018; 5(4): 5.
[http://dx.doi.org/10.3390/jcdd5040051] [PMID: 30347794]
[9]
Khazem S, Itani L, Kreidieh D, et al. Reduced lean body mass and cardiometabolic diseases in adult males with overweight and obesity: a pilot study. Int J Environ Res Public Health 2018; 15(12): 15.
[http://dx.doi.org/10.3390/ijerph15122754] [PMID: 30563167]
[10]
Farmer RE, Mathur R, Schmidt AF, et al. Associations between measures of sarcopenic obesity and risk of cardiovascular disease and mortality: a cohort study and mendelian randomization analysis using the UK Biobank. J Am Heart Assoc 2019; 8(13)e011638
[http://dx.doi.org/10.1161/JAHA.118.011638] [PMID: 31221000]
[11]
Khadra D, Itani L, Tannir H, Kreidieh D, El Masri D, El Ghoch M. Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis. World J Diabetes 2019; 10(5): 311-23.
[http://dx.doi.org/10.4239/wjd.v10.i5.311] [PMID: 31139318]
[12]
Atkins JL, Wannamethee SG. The effect of sarcopenic obesity on cardiovascular disease and all-cause mortality in older people. Rev Clin Gerontol 2015; 25: 86-97.
[http://dx.doi.org/10.1017/S0959259815000076]
[13]
Barazzoni R, Bischoff SC, Boirie Y, et al. Sarcopenic obesity: Time to meet the challenge. Clin Nutr 2018; 37(6 Pt A): 1787-93.
[http://dx.doi.org/10.1016/j.clnu.2018.04.018] [PMID: 29857921]
[14]
Garratt A, Schmidt L, Mackintosh A, Fitzpatrick R. Quality of life measurement: bibliographic study of patient assessed health outcome measures. BMJ 2002; 324(7351): 1417.
[http://dx.doi.org/10.1136/bmj.324.7351.1417] [PMID: 12065262]
[15]
Testa MA, Simonson DC. Assessment of quality-of-life outcomes. N Engl J Med 1996; 334(13): 835-40.
[http://dx.doi.org/10.1056/NEJM199603283341306] [PMID: 8596551]
[16]
Itani L, Calugi S, Kreidieh D, et al. Validation of an arabic version of the obesity-related wellbeing (ORWELL 97) questionnaire in adults with obesity. Curr Diabetes Rev 2019; 15(2): 127-32.
[http://dx.doi.org/10.2174/1573399814666180111111934] [PMID: 29332589]
[17]
Kroes M, Osei-Assibey G, Baker-Searle R, Huang J. Impact of weight change on quality of life in adults with overweight/obesity in the United States: a systematic review. Curr Med Res Opin 2016; 32(3): 485-508.
[http://dx.doi.org/10.1185/03007995.2015.1128403] [PMID: 26652030]
[18]
Itani L, Calugi S, Dalle Grave R, et al. The association between body mass index and health-related quality of life in treatment-seeking arab adults with obesity. Med Sci (Basel) 2018; 6(1): 6.
[http://dx.doi.org/10.3390/medsci6010025] [PMID: 29534025]
[19]
El Ghoch M, Fakhoury R. Challenges and new directions in obesity management: lifestyle modification programmes, pharmacotherapy and bariatric surgery. J Popul Ther Clin Pharmacol 2019; 26(2): e1-4.
[PMID: 31577079]
[20]
Messier V, Karelis AD, Lavoie ME, et al. Metabolic profile and quality of life in class I sarcopenic overweight and obese postmenopausal women: a MONET study. Appl Physiol Nutr Metab 2009; 34(1): 18-24.
[http://dx.doi.org/10.1139/H08-135] [PMID: 19234581]
[21]
Silva Neto LS, Karnikowiski MG, Tavares AB, Lima RM. Association between sarcopenia, sarcopenic obesity, muscle strength and quality of life variables in elderly women. Rev Bras Fisioter 2012; 16(5): 360-7.
[http://dx.doi.org/10.1590/S1413-35552012005000044] [PMID: 22983215]
[22]
Öztürk ZA, Türkbeyler IH, Abiyev A, et al. Health-related quality of life and fall risk associated with age-related body composition changes; sarcopenia, obesity and sarcopenic obesity. Intern Med J 2018; 48(8): 973-81.
[http://dx.doi.org/10.1111/imj.13935] [PMID: 29665258]
[23]
Johnson Stoklossa CA, Sharma AM, Forhan M, Siervo M, Padwal RS, Prado CM. Prevalence of sarcopenic obesity in adults with class ii/iii obesity using different diagnostic criteria. J Nutr Metab 2017; 20177307618
[http://dx.doi.org/10.1155/2017/7307618] [PMID: 28421144]
[24]
Oh C, Jho S, No JK, Kim HS. Body composition changes were related to nutrient intakes in elderly men but elderly women had a higher prevalence of sarcopenic obesity in a population of Korean adults. Nutr Res 2015; 35(1): 1-6.
[http://dx.doi.org/10.1016/j.nutres.2014.07.018] [PMID: 25524331]
[25]
Mannucci E, Petroni ML, Villanova N. QUOVADIS Study Group.Clinical and psychological correlates of health-related quality of life in obese patients. Health Qual Life Outcomes 2010; 8: 90.
[http://dx.doi.org/10.1186/1477-7525-8-90] [PMID: 20731871]
[26]
El Ghoch M, Calugi S, Dalle Grave R. Weight cycling in adults with severe obesity: A longitudinal study. Nutr Diet 2018; 75(3): 256-62.
[http://dx.doi.org/10.1111/1747-0080.12387] [PMID: 29114979]
[27]
Kelly J, Metcalfe J. Validity and reliability of body composition analysis using the tanita BC418-MA. J Exerc Physiol 2012; 15: 74-86.
[28]
Lee L, Hsieh K, Wu C, Chen Y, Chiang J, Chen Y. Validity of standing posture eight-electrode bioelectrical impedance to estimate body composition in taiwanese elderly. Int J Gerontol 2014; 8: 137-42.
[http://dx.doi.org/10.1016/j.ijge.2013.08.010]
[29]
Mannucci E, Ricca V, Barciulli E, et al. Quality of life and overweight: the obesity related well-being (Orwell 97) questionnaire. Addict Behav 1999; 24(3): 345-57.
[http://dx.doi.org/10.1016/S0306-4603(98)00055-0] [PMID: 10400274]
[30]
Camolas J, Ferreira A, Mannucci E, et al. Assessing quality of life in severe obesity: development and psychometric properties of the ORWELL-R. Eat Weight Disord 2016; 21(2): 277-88.
[http://dx.doi.org/10.1007/s40519-015-0222-z] [PMID: 26429794]
[31]
Mannucci E, Ricca V, Barciulli E, et al. Obesity-Related WELLbeing questionnaire (ORWELL 97). Clinica psicologica dell’obesità. Milano: Springer 2012; 293-7.
[http://dx.doi.org/10.1007/978-88-470-2007-8_20]
[32]
Jensen B, Braun W, Geisler C, et al. Limitations of fat-free mass for the assessment of muscle mass in obesity. Obes Facts 2019; 12(3): 307-15.
[http://dx.doi.org/10.1159/000499607] [PMID: 31132777]
[33]
Solem RC. Limitation of a cross-sectional study. Am J Orthod Dentofacial Orthop 2015; 148(2): 205.
[http://dx.doi.org/10.1016/j.ajodo.2015.05.006] [PMID: 26232823]
[34]
Kolotkin RL, Andersen JR. A systematic review of reviews: exploring the relationship between obesity, weight loss and health-related quality of life. Clin Obes 2017; 7(5): 273-89.
[http://dx.doi.org/10.1111/cob.12203] [PMID: 28695722]
[35]
Kirk B, Mooney K, Cousins R, et al. Effects of exercise and whey protein on muscle mass, fat mass, myoelectrical muscle fatigue and health-related quality of life in older adults: a secondary analysis of the Liverpool Hope University-Sarcopenia Ageing Trial (LHU-SAT). Eur J Appl Physiol 2020; 120(2): 493-503.
[http://dx.doi.org/10.1007/s00421-019-04293-5] [PMID: 31894414]


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Article Details

VOLUME: 16
ISSUE: 6
Year: 2020
Page: [635 - 640]
Pages: 6
DOI: 10.2174/1573399816666200211102057
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