Background: There is a paucity of studies on health-related quality of life (HRQoL) and
sarcopenic obesity (SO).
Objective: This study aimed to assess the potential association between SO and impaired HRQoL.
Methods: The ORWELL 97 questionnaire was used to assess HRQoL and body composition was measured
using a bioimpedance analyser (Tanita BC-418) in 130 patients with obesity, referred to the Nutritional
and Weight Management outpatient clinic of Beirut Arab University in Lebanon. Participants
were then categorized on the basis of the absence or presence of SO.
Results: Sixty-four of the 130 participants met the criteria for SO (49.2%) and displayed significantly
higher total ORWELL 97 scores than those in the group without SO (64.00 vs. 41.00, p=0.001), indicative
of poorer HRQoL. Linear regression analysis showed that SO was associated with an increase in
ORWELL 97 scores by nearly 24 units (β=24.35, 95% CI=11.45-37.26; p<0.0001). Moreover, the logistic
regression analysis showed that SO increased the odds of clinically significant impairment of
HRQoL (ORWELL 97 score ≥74.25) by nearly seven-fold (OR=7.37, 95% CI=1.92-28.39; p=0.004).
Conclusion: Our findings show that the presence of SO was associated with increased impairment of
HRQoL that reaches clinical significance when compared to obesity only. Future studies are needed to
clarify whether this may influence clinical outcomes. If this is shown to be the case, weight management
programs should incorporate additional strategies to improve HRQoL in individuals with SO.