A Simple Synthesis of the Anticancer Drug Altretamine

Author(s): Vu Binh Duong, Pham Van Hien, Tran Thai Ngoc, Phan Dinh Chau, Tran Khac Vu*

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 8 , 2020

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Abstract:

A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.

Keywords: Altretamine, hexamethylmelamine, cyanuric chloride, dimethylamine, antitumor, potassium hydroxide, sodium hydroxide.

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Article Details

VOLUME: 17
ISSUE: 8
Year: 2020
Page: [628 - 630]
Pages: 3
DOI: 10.2174/1570178617666200210111041
Price: $65

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