The non-enzymatic interaction of sugar and protein resulting in the formation of advanced
glycation end products responsible for cell signaling alterations ultimately leads to the human chronic
disorders such as diabetes mellitus, cardiovascular diseases, cancer, etc. Studies suggest that AGEs
upon interaction with receptors for advanced glycation end products (RAGE) result in the production
of pro-inflammatory molecules and free radicals that exert altered gene expression effect. To date,
many studies unveiled the potent role of synthetic and natural agents in inhibiting the glycation reaction
at a lesser or greater extent. This review focuses on the hazards of glycation reaction and its inhibition
by natural antioxidants, including polyphenols.
Keywords: Glycation, advanced glycation end-products, diabetic complications, antiglycation, polyphenols, antioxidants.
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