New Challenges and Strategies for Cardiac Disease: Autophagy, mTOR, and AMP-activated Protein Kinase

Author(s): Kenneth Maiese*

Journal Name: Current Neurovascular Research

Volume 17 , Issue 2 , 2020

Become EABM
Become Reviewer

Heron M. Deaths: Leading causes for 2017. Nat Vital Stat Reports 2019; 68(6): 1-77.
Maiese K. Healing the heart with sirtuins and mammalian forkhead transcription factors. Curr Neurovasc Res 2020; 17(1): 1-2.
Fryar C, Chen T, Li X. Prevalence of uncontrolled risk factors for cardiovascular disease: United States, 1999-2010. Nat Center Health Stat Data Brief 2012; 103: 1-8.
Maiese K. Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders. Br J Clin Pharmacol 2016; 82(5): 1245-66.
Preau S, Ambler M, Sigurta A, et al. Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle. Am J Physiol Regul Integr Comp Physiol 2019; 316(5): R584-93.
Wang Y, Le WD. Autophagy and Ubiquitin-proteasome system. Adv Exp Med Biol 2019; 1206: 527-50.
Zhang N, Zhao Y. Other molecular mechanisms regulating autophagy. Adv Exp Med Biol 2019; 1206: 261-71.
Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2016; 12(1): 1-222.
Maiese K. mTOR: Driving apoptosis and autophagy for neurocardiac complications of diabetes mellitus. World J Diabetes 2015; 6(2): 217-24.
Maiese K, Chong ZZ, Shang YC, Wang S. Targeting disease through novel pathways of apoptosis and autophagy. Expert pinion on therapeutic targets 2012; 16(12): 1203-14.
Maiese K. The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): Oversight for neurodegenerative disorders. Biochem Soc Trans 2018; 46(2): 351-60.
Maiese K. Novel treatment strategies for the nervous system: Circadian clock genes, non-coding RNAs, and forkhead transcription factors. Curr Neurovasc Res 2018; 15(1): 81-91.
Chiu SC, Chao CY, Chiang EI, Syu JN, Rodriguez RL, Tang FY. N-3 polyunsaturated fatty acids alleviate high glucose-mediated dysfunction of endothelial progenitor cells and prevent ischemic injuries both in vitro and in vivo. Journal of nutritional biochemistry 2017; 42: 172-81.
Du LL, Chai DM, Zhao LN, et al. AMPK activation ameliorates Alzheimer’s disease-like pathology and spatial memory impairment in a Streptozotocin-induced Alzheimer’s disease model in rats. J Alzheimers Dis 2015; 43(3): 775-84.
Jiang T, Yu JT, Zhu XC, et al. Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. Br J Pharmacol 2014; 171(13): 3146-57.
Maiese K. Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of Rapamycin and circadian clock gene pathways. Expert Rev Clin Pharmacol 2020; 13(1): 23-34.
Maiese K. Harnessing the power of SIRT1 and non-coding RNAs in vascular disease. Curr Neurovasc Res 2017; 14(1): 82-8.
Peixoto CA, de Oliveira WH, da Rocha Araujo SM, Nunes AKS. AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration. Exp Neurol 2017; 298(Pt A): 31-41.
Dong Y, Chen H, Gao J, Liu Y, Li J, Wang J. Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease. J Mol Cell Cardiol 2019; 136: 27-41.
Maiese K. SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. World J Stem Cells 2015; 7(2): 235-42.
Tong J, Lai Y, Yao YA, et al. Qiliqiangxin rescues mouse cardiac function by regulating AGTR1/TRPV1-mediated autophagy in STZ-induced diabetes mellitus. Cell Physiol Biochem 2018; 47(4): 1365-76.
Pasini E, Flati V, Paiardi S, et al. Intracellular molecular effects of insulin resistance in patients with metabolic syndrome. Cardiovasc Diabetol 2010; 9: 46.
Lassaletta AD, Elmadhun NY, Zanetti AV, et al. Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis. Ann Thorac Surg 2014; 97(3): 901-7.
Zhou Y, Fang H, Lin S, et al. Qiliqiangxin protects against cardiac ischemia-reperfusion injury via activation of the mTOR pathway. Cell Physiol Biochem 2015; 37(2): 454-64.
Zhang HM, Fu J, Hamilton R, Diaz V, Zhang Y. The mammalian target of rapamycin modulates the immunoproteasome system in the heart. J Mol Cell Cardiol 2015; 86: 158-67.
Zhao Z, Liu H, Guo D. Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways. Braz J Med Biol Res 2020; 53(2)e8793
Lai YF, Wang L, Liu WY. Nicotinamide pretreatment alleviates mitochondrial stress and protects hypoxic myocardial cells via AMPK pathway. European Rev Med Pharmacol Sci 2019; 23(4): 1797-806.
Liu Y, Palanivel R, Rai E, et al. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes 2014; 64(1): 36-48.
Maiese K. FoxO proteins in the nervous system. Anal Cell Pathol (Amst) 2015; 2015 :569392
Pal PB, Sonowal H, Shukla K, Srivastava SK, Ramana KV. Aldose reductase regulates hyperglycemia-induced HUVEC death via SIRT1/AMPK-alpha1/ mTOR pathway. J Mol Endocrinol 2019; 63(1): 11-25.
Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3 beta increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Reports 2016; 36(5) : piie00382
Zhang H, Yang X, Pang X, Zhao Z, Yu H, Zhou H. Genistein protects against ox-LDL-induced senescence through enhancing SIRT1/LKB1/AMPK mediated autophagy flux in HUVECs. Mol Cell Biochem 2019; 455(1-2): 127-34.
Shokri Afra H, Zangooei M, Meshkani R, et al. Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells. J Physiol Biochem 2019; 75: 125-33.
Zhao D, Sun X, Lv S, et al. Salidroside attenuates oxidized low density lipoprotein induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway. Int J Mol Med 2019; 43(6): 2279-90.
Martino L, Masini M, Novelli M, et al. Palmitate activates autophagy in INS-1E beta-cells and in isolated rat and human pancreatic islets. PLoS ONE 2012; 7(5)e36188
Kim KA, Shin YJ, Akram M, et al. High glucose condition induces autophagy in endothelial progenitor cells contributing to angiogenic impairment. Biol Pharm Bull 2014; 37(7): 1248-52.
Wang L, Wu W, Chen J, Li Y, Xu M, Cai Y. miR122 and miR199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway. Int J Mol Med 2019; 43(3): 1373-81.
Maiese K. Taking aim at Alzheimer's disease through the mammalian target of Rapamycin. Ann Med 2014; 46(8): 587-96.

promotion: free to download

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2020
Published on: 04 August, 2020
Page: [111 - 112]
Pages: 2
DOI: 10.2174/1567202617999200207153935

Article Metrics

PDF: 14
PRC: 1