Title:Early Age of Migraine Onset is Independently Related to Cognitive Decline and Symptoms of Depression Affect Quality of Life
VOLUME: 17 ISSUE: 2
Author(s):Jiajia Bao, Mengmeng Ma, Shuju Dong, Lijie Gao, Changling Li, Chaohua Cui, Ning Chen, Yang Zhang and Li He*
Affiliation:Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan
Keywords:Migraine, headache, age of migraine onset, cognitive function, cognitive decline, quality of life, anxiety symptom,
depression symptom.
Abstract:
Background: People with migraine experience cognitive decline more often than
healthy controls, resulting in a significant functional impact. Early identifying influencing factors
that contribute to cognitive decline in migraineurs is crucial for timely intervention. Although
migraine may onset early in childhood and early onset migraine is related to significant disability,
there is no research investigating the association between the age of migraine onset and
migraineurs’ cognitive decline. Therefore we aim to explore possible factors that correlate to the
cognitive function of migraineurs, especially focus on age of migraine onset.
Methods: 531 patients with migraine were included. Data on demographics and headache-related
characteristics were collected and evaluated using face-to-face interviews and questionnaires. We
used the Montreal Cognitive Assessment scale to assess cognitive function. In addition, we analyzed
independent correlations between cognitive decline and the age of migraine onset in patients
with migraine. And all patients completed the Headache Impact Test-6 to evaluate their quality of
life.
Results: Migraineurs with cognitive decline showed significant differences from those without in
age (OR=1.26, P<0.0001), years of education (OR=0.89, P=0.0182), the intensity of headache
(OR=1.03, P=0.0217), age of onset (OR=0.92, P<0.0001) and anxiety scores (OR=1.09,
P=0.0235). Furthermore, there was no interaction in the age of onset between subgroups. Multivariate
linear regression analyses of HIT-6 scores showed that the intensity of headache (β=0.18,
P<0.0001) and depression scores (β=0.26, P=0.0009) had independent effects on decreased quality
of life.
Conclusion: Our findings suggest that younger age of migraine onset is independently related to
migraineurs’ cognitive decline, and migraine accompanying anxiety symptoms significantly
related to decreased quality of life in migraineurs.
