In-Situ Synthesis of Active Pharmaceutical Ingredients Which Content Pyrazole Skeleton

Author(s): Pathan Sultan Ismail, Repale Anil Vithal, Girdhar Pal Singh*

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 10 , 2020

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Abstract:

Celecoxib containing pyrazole derivatives were synthesized by path aldol condensation of substituted ketone with trifluoroethyl acetate subsequently by cyclization of the formed chalcones with 4-methanesulfonylphenylhydrazine. Here, a one-pot synthesis of celecoxib and substituted analogues have been reported which are nonsteroidal anti-inflammatory drugs for their cyclooxygenase (COX) inhibition, anti-inflammatory activity and ulcerogenic liability. In order to intermediate work-up, a continuous one-pot synthesis has been developed, performing the entire reaction sequence that results in a shorter time with good yield.

Keywords: Pyrazoles, Claisen condensation, Cyclization, API, COX-1, COX-2.

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Article Details

VOLUME: 17
ISSUE: 10
Year: 2020
Page: [743 - 747]
Pages: 5
DOI: 10.2174/1570178617666200207110526
Price: $95

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