A simple and efficient methodology for Friedel-Crafts acylation of 3-methylindole using
Amberlyst 15 resin as catalyst is described. This methodology shows good selectivity towards the formation
of the products of 2-acylation, (3-methyl-1H-indol-2-yl)ketones. Several advantages can be ascribed
to Amberlyst 15, among them; are the ease of handling, quick separation from the reaction mixture
and minimum or no production of the chemical residues that must be eliminated. Besides, the catalyst
can be easily recycled and reused with a minimal loss in activity through 6 reaction cycles. The
catalyst was characterized by FT-IR spectroscopy and superficial acidity.
Keywords: Amberlyst 15, 3-Methylindole, Acylation reaction, Friedel-Crafts, ketones, acylindoles.
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