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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

An Effective Assembling of Novel Derivatives Containing Both Benzo[d]thiazole and Benzo[d]oxazole Rings

Author(s): Nguyen Thi Ngoc Mai, Duong Quoc Hoan*, Vu Thi Anh Tuyet, Tran Thi Thu Trang, Duong Khanh Linh and Trinh Thi Huan

Volume 17, Issue 11, 2020

Page: [815 - 822] Pages: 8

DOI: 10.2174/1570178617666200207104912

Price: $65

Abstract

A novel series of 5-(benzo[d]thiazol-2-yl)benzo[d]oxazole-based compounds was synthesized in four linear steps in high yield from vanillin. Both benzo[d]thiazole and benzo[d]oxazole cyclizations were assisted with a domestic microwave oven in about 4-8 minutes in which the yield of the benzo[d]oxazole cyclization was up to 92%. Structures of the new synthesized compounds were elucidated by spectral data.

Keywords: Benzo[d]thiazole, benzo[d]oxazole, microwave, vanillin, cyclization, formylation reaction.

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