An Effective Assembling of Novel Derivatives Containing Both Benzo[d]thiazole and Benzo[d]oxazole Rings

Author(s): Nguyen Thi Ngoc Mai, Duong Quoc Hoan*, Vu Thi Anh Tuyet, Tran Thi Thu Trang, Duong Khanh Linh, Trinh Thi Huan

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 11 , 2020

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Graphical Abstract:


A novel series of 5-(benzo[d]thiazol-2-yl)benzo[d]oxazole-based compounds was synthesized in four linear steps in high yield from vanillin. Both benzo[d]thiazole and benzo[d]oxazole cyclizations were assisted with a domestic microwave oven in about 4-8 minutes in which the yield of the benzo[d]oxazole cyclization was up to 92%. Structures of the new synthesized compounds were elucidated by spectral data.

Keywords: Benzo[d]thiazole, benzo[d]oxazole, microwave, vanillin, cyclization, formylation reaction.

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Article Details

Year: 2020
Published on: 29 November, 2020
Page: [815 - 822]
Pages: 8
DOI: 10.2174/1570178617666200207104912
Price: $65

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