The prevalence of liver cancer is increasing over the years and it is the fifth leading cause of
mortality worldwide. The intrusive features and burden of low survival rate make it a global health issue
in both developing and developed countries. The recommended chemotherapy drugs for patients in the
intermediate and advanced stages of various liver cancers yield a low response rate due to the nonspecific
nature of drug delivery, thus warranting the search for new therapeutic strategies and potential drug
delivery carriers. There are several new drug delivery methods available to ferry the targeted molecules
to the specific biological environment. In recent years, the nano assembly of lipoprotein moieties (lipidic
nanoparticles) has emerged as a promising and efficiently tailored drug delivery system in liver cancer
treatment. This increased precision of nano lipoproteins conjugates in chemotherapeutic targeting offers
new avenues for the treatment of liver cancer with high specificity and efficiency. This present review is
focused on concisely outlining the knowledge of liver cancer diagnosis, existing treatment strategies,
lipoproteins, their preparation, mechanism and their potential application in the treatment of liver cancer.
Keywords: Liver cancer, lipoproteins, LDL, HDL, receptor lipidic nanoparticle, ligand-target, drug delivery systems, anticancer
drugs, therapeutic application.
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