Stem-Cell Derived Exosomes for the Treatment of Osteoarthritis

Author(s): Zekai Ke, Jinyu Zhu*

Journal Name: Current Stem Cell Research & Therapy

Volume 15 , Issue 7 , 2020

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Abstract:

Osteoarthritis(OA) is a common degenerative orthopedic disease with multiple pathologic changes in joints affecting large populations worldwide. No treatment can reverse the progress of OA. Since exosomes were first reported in 1983, researches have been conducted to explore the mechanisms and therapeutic potential of exosomes in treating OA. Exosomes derived from Mesenchymal stem cells have attracted increasing attention in tackling the disease. This article summarizes the current advances and challenges in exosomes for OA, which may providea reference for further research.

Keywords: MSC exosomes, exosomes, osteoarthritis, micro-RNA, cytokines, microenvironment.

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Article Details

VOLUME: 15
ISSUE: 7
Year: 2020
Page: [597 - 601]
Pages: 5
DOI: 10.2174/1574888X15666200206104332
Price: $65

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