Monitoring the appropriate functions of the brain is a priority when the diagnosis
of neurological diseases is carried out. In this regard, there are different analytical
techniques to detect neurotransmitters and other molecules with biological activity in
the nervous system. Among several analytical procedures, electrochemical techniques are
very important since they can be applied in situ, without loss of sensibility and/or minimal
handling of samples. In addition, it is also possible to combine them with specific detectors
designed on the basis of chemically-modified electrodes in order to improve detection
limits by promoting molecular recognition capabilities at their surfaces, thus favoring the
development of electrochemical detection in vivo by microelectrodes. In this mini-review,
we will describe the major characteristics of this analytical method and its advantages for
the detection of neurotransmitters (mostly dopamine) in vivo.
Keywords: Electroanalysis, neurotransmitters, biological activity, central nervous system, chromatography, modified electrode.
Rights & PermissionsPrintExport