Cellular Retinoic-Acid Binding Protein 2 in Solid Tumor

Author(s): Xiaoyang Jiao*, Rang Liu, Jiali Huang, Lichun Lu, Zibo Li, Liyan Xu, Enmin Li*.

Journal Name: Current Protein & Peptide Science

Volume 21 , Issue 5 , 2020

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Graphical Abstract:


The retinoic acid (RA) signaling pathway is crucial for many biological processes. The RA transporter, Cellular Retinoic-Acid Binding Protein 2 (CRABP2), is abnormally expressed in various tumor types. CRABP2 presents significant effects on tumorous behaviors and functions, including cell proliferation, apoptosis, invasion, migration, metastasis, and angiogenesis. The tumorigenesis mechanism of CRABP2, as both suppressor and promotor, is complicated, therefore, there remains the need for further investigation. Elucidating the regulating mechanisms in a specific stage of the tumor could facilitate CRABP2 to be a biomarker in cancer diagnosis and prognosis. Besides, clarifying the pathways of CRABP2 in cancer development will contribute to the gene-targeted therapy. In this review, we summarized the expression, distribution, and mechanism of CRABP2 in solid tumors. Illuminating the CRABP2 signaling pathway may benefit understanding the retinoid signaling pathway, providing a useful biomarker for future clinical trials.

Keywords: CRABP2, Retinoic-acid, signaling pathway, tumor, protein, solid tumor.

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Article Details

Year: 2020
Page: [507 - 516]
Pages: 10
DOI: 10.2174/1389203721666200203150721
Price: $65

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