Mechanisms of Activation and Key Roles of SGK3 Under Physiological Conditions and in Prostate and Breast Cancer.

(E-pub Ahead of Print)

Author(s): Rajesh Basnet*, Buddha Bahadur Basnet

Journal Name: Current Signal Transduction Therapy

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Abstract:

The serum and glucocorticoid inducible protein kinase (SGK) family signals downstream of phosphoinositide-3-kinase (PI3K) and is made up of three isoforms: SGK1, 2, and 3. respectively, and their activity is dependent on growth factor activation. Among these SGK family one such potential target and less explored enzyme is SGK3. SGK3 regulate a range of basic cellular processes, such as cell proliferation, migration and survival. Thus play an important role in cancer development. These kinase-signaling pathways present both opportunities and challenges for cancer therapy. In this paper, we reviewed the status of SGK3 regulation and its role in normal cell physiology and transformation. In addition, the potential roles of SGK3 signal transduction in breast cancer and prostate cancer are discussed.

Keywords: SGK3, AKT, PI3K, INPP4B, mTOR, Breast cancer, Prostate cancer

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(E-pub Ahead of Print)
DOI: 10.2174/1574362415666200203122829