Background: Cancer is one of the most prevalent diseases associated with heavy complications
in treatment. Mucotoxic cancer therapies such as head and neck radiotherapy and some
of the chemotherapy agents may lead to oral mucositis. In addition to its economic consequences,
mucositis also affects patients' quality of life. In Traditional Persian Medicine (TPM) manuscripts,
several medicaments have been suggested for the treatment of mucositis.
Objective: Considering the public welcome for herbal medicine, the current evidence-based review
study is conducted to investigate the herbal remedies which have been proposed for oral mucositis
Methods: At first, a comprehensive survey was done on Qanon fi al-Teb, which is the most important
textbook of TPM; then the scientific name of the herbs was authenticated according to the
botanical textbooks. At last, data banks including Scopus, Pubmed, Web of science and Science
direct were investigated for possible relevant properties of each medicinal plant in the literature.
Results: In total, 30 herbs are introduced in this study. According to the registered documents, 18
herbs are reported to have antioxidant, anti-inflammatory, antimicrobial, anti-nociceptive and
wound healing properties of which the therapeutic effect of only a few herbs including Glycyrrhiza
glabra, Malva sylvestris, Morus nigra, Punica granatum, and Solanum nigrum were directly evaluated
against oral mucositis on the literature.
Conclusion: Despite the lack of human studies on mucositis for the other discussed herbs, their related
pharmacological properties can be considered for new natural drug discovery supported by
medieval and traditional experiments.