Stress Response and Immunity: Links and Trade Offs

Stress Response and Immunity: Links and Trade Offs

When environmental conditions deviate from the optimal range, stress ensues. Stress response is a set of reactions that allow the organism to adjust and survive adverse conditions. Stress can be ...
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p53, Guardian of the Genome

Pp. 224-256 (33)

Nadia Danilova

Abstract

p53 is the most important tumor suppressor. It arrests cell cycle in response to stress, stimulates DNA repair, and induces senescence or apoptosis of cells that have unrepairable damage. p53 level and activity are kept low by the E3 ubiquitin ligase Mdm2, which ubiquitinates p53 targeting it for proteasomal degradation. Additional post-translational modifications of p53 such as phosphorylation, methylation, acetylation, and others, signal the cell’s internal condition to p53 and modulate its activity.

Keywords:

ATM, ATR, Apoptosis, Cell cycle, Cell cycle arrest, Cancer, DNA damage, Mdm2, p53, p63, p73, Tumor suppressor.

Affiliation:

Department of Molecular Cell & Developmental Biology, University of California, Los Angeles CA, USA.