Background: The present study was conducted to evaluate the mitigating effects of Asiatic
Acid (AA), on the changes in carbohydrate metabolism, insulin signaling molecules and renal
function markers in Streptozotocin (STZ)-Nicotinamide (NAD) induced diabetic rats.
Methods: AA (20 mg/kg BW) was supplemented orally to the diabetic rats for 42 days. The levels of
plasma glucose, Hemoglobin (Hb), glycosylated hemoglobin (HbA1c) insulin and renal function
markers, carbohydrate metabolic enzymes in the kidney and insulin signaling molecules in skeletal
muscle were measured.
Results: The administration of AA elicited a significant decrease in the levels of plasma glucose, insulin
resistance, HbA1c, urea, uric acid, creatinine, glycogen, glycogen synthase, glucose-6-
phosphatase, and fructose-1,6-bisphosphatase and a significant increase of body weight development,
insulin, Hb, hexokinase, and glycogen phosphorylase and mRNA expressions of insulin signaling
molecule like insulin receptor 1, insulin receptor 2 and glucose transporter-4 in the STZ-NAD induced
diabetic rats. Further, the protective effect of AA was evidenced by its histological annotation
of the kidney tissues.
Conclusion: Hence, this study concluded that AA can protect against renal dysfunction by attenuating
carbohydrate metabolic disorder and subsequently enhances glucose utilization and renal function
in STZ-NAD-induced diabetic rats.