1, 3, 5-Triazine (s-Triazine) is a versatile nucleus to design and develop potent bioactive
molecules for drug discovery, particularly in cancer therapy. The aim of this review is to present the
most recent trends in the field of synthetic strategies made for functionalized triazine derivatives active
against cell proliferation. This review article covers the synthesis of aryl methylamino, morpholino,
triamino substituted triazines, antimitotic agents coupled triazines and many more. Many 1,3,5-
triazine derivatives, both hetero-fused and uncondensed, have shown remarkable antitumor activities.
We have highlighted various derivatives with 1, 3, 5-triazine core targeting different kinases with an
aim to help researchers for developing new 1, 3, 5-triazine derived compounds for antitumor activity.